The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …

Pancreatic islet transplantation has become an established approach to β-cell replacement
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …

The main goal of treatment for type 1 diabetes is to control glycaemia with insulin therapy to
reduce disease complications. For some patients, technological approaches to insulin …

For patients with type 1 diabetes, it is accepted among the scientific community that there is
a marked reduction in β-cell mass; however, with type 2 diabetes, there is disagreement as …

Summary β‐cell replacement therapy, available currently as pancreas or islet
transplantation, has developed without a clear definition of graft functional and clinical …

Problematic hypoglycemia, defined as two or more episodes per year of severe
hypoglycemia or as one episode associated with impaired awareness of hypoglycemia …

The incidence of esophageal adenocarcinoma (EAC) has increased in recent decades, and
its 5-year survival rate is less than 20%. As a well-established precursor, patients with …

Diabetes Mellitus is a group of diseases characterized by high blood glucose levels due to
patients' inability to produce sufficient insulin. Current interventions often require implants …

Islet cell transplantation is a promising beta cell replacement therapy for patients with brittle
type 1 diabetes as well as refractory chronic pancreatitis. Despite the vast advancements …

OBJECTIVE To determine long-term outcomes for islet-alone and islet-after-kidney
transplantation in adults with type 1 diabetes complicated by impaired awareness of …