Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery

ML Merchant, IM Rood, JKJ Deegens… - Nature Reviews …, 2017 - nature.com
Urine is a valuable diagnostic medium and, with the discovery of urinary extracellular
vesicles, is viewed as a dynamic bioactive fluid. Extracellular vesicles are lipid-enclosed …

The potential of endurance exercise-derived exosomes to treat metabolic diseases

A Safdar, A Saleem, MA Tarnopolsky - Nature Reviews Endocrinology, 2016 - nature.com
Endurance exercise-mediated multisystemic adaptations are known to mitigate metabolism-
related disorders such as obesity and type 2 diabetes mellitus (T2DM). However, the …

Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles

U Erdbrügger, CJ Blijdorp, IV Bijnsdorp… - Journal of …, 2021 - Wiley Online Library
Urine is commonly used for clinical diagnosis and biomedical research. The discovery of
extracellular vesicles (EV) in urine opened a new fast‐growing scientific field. In the last …

Exosomal ncRNAs: Novel therapeutic target and biomarker for diabetic complications

YX Xu, SD Pu, X Li, ZW Yu, YT Zhang, XW Tong… - Pharmacological …, 2022 - Elsevier
Exosomes are discoid vesicles with a diameter of 40–160 nm. They are mainly derived from
the multivesicular body formed by the invagination of lysosomal particles in the cell, which …

Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine

B Dhondt, E Geeurickx, J Tulkens… - Journal of …, 2020 - Taylor & Francis
Extracellular vesicles (EV) are increasingly being recognized as important vehicles of
intercellular communication and promising diagnostic and prognostic biomarkers in cancer …

Roles for exosome in various kidney diseases and disorders

V Thongboonkerd - Frontiers in pharmacology, 2020 - frontiersin.org
Exosome is a nanoscale vesicle with a size range of 30–100 nm. It is secreted from cell to
extracellular space by exocytosis after fusion of multivesicular body (MVB)(formed by …

Potential role of serum and urinary biomarkers in diagnosis and prognosis of diabetic nephropathy

CG Campion, O Sanchez-Ferras… - Canadian journal of …, 2017 - journals.sagepub.com
Purpose of review: Diabetic nephropathy (DN) is a progressive kidney disease caused by
alterations in kidney architecture and function, and constitutes one of the leading causes of …

Emerging technologies and commercial products in exosome-based cancer diagnosis and prognosis

M Mohammadi, H Zargartalebi, R Salahandish… - Biosensors and …, 2021 - Elsevier
Academic and industrial groups worldwide have reported technological advances in
exosome-based cancer diagnosis and prognosis. However, the potential translation of these …

Extracellular vesicles in diagnosis and therapy of kidney diseases

W Zhang, X Zhou, H Zhang, Q Yao… - American Journal of …, 2016 - journals.physiology.org
Extracellular vesicles (EV) are endogenously produced, membrane-bound vesicles that
contain various molecules. Depending on their size and origins, EVs are classified into …

Human saliva-derived exosomes: comparing methods of isolation

A Zlotogorski-Hurvitz, D Dayan… - … of Histochemistry & …, 2015 - journals.sagepub.com
ExoQuick-TCTM (EQ), a chemical-based agent designed to precipitate exosomes, was
calibrated for use on saliva collected from healthy individuals. The morphological and …