Adult neurogenesis and mental illness

TJ Schoenfeld, HA Cameron - Neuropsychopharmacology, 2015 - nature.com
Several lines of evidence suggest that adult neurogenesis, the production of new neurons in
adulthood, may play a role in psychiatric disorders, including depression, anxiety, and …

The transcription factor Zif268/Egr1, brain plasticity, and memory

A Veyrac, A Besnard, J Caboche, S Davis… - Progress in molecular …, 2014 - Elsevier
The capacity to remember our past experiences and organize our future draws on a number
of cognitive processes that allow our brain to form and store neural representations that can …

Physical exercise prevents stress-induced activation of granule neurons and enhances local inhibitory mechanisms in the dentate gyrus

TJ Schoenfeld, P Rada, PR Pieruzzini… - Journal of …, 2013 - Soc Neuroscience
Physical exercise is known to reduce anxiety. The ventral hippocampus has been linked to
anxiety regulation but the effects of running on this subregion of the hippocampus have …

[HTML][HTML] Test, rinse, repeat: A review of carryover effects in rodent behavioral assays

V Cnops, VR Iyer, N Parathy, P Wong… - … & Biobehavioral Reviews, 2022 - Elsevier
Behavioral phenotyping has been gaining prominence due to the increased use of
transgenic animal models of neurological disorders. Repeated testing in the same cohort of …

Zif268/egr1 gene controls the selection, maturation and functional integration of adult hippocampal newborn neurons by learning

A Veyrac, A Gros, E Bruel-Jungerman… - Proceedings of the …, 2013 - National Acad Sciences
New neurons are continuously added to the dentate gyrus of the adult mammalian brain.
During the critical period of a few weeks after birth when newborn neurons progressively …

Cognitive flexibility is selectively impaired by radiation and is associated with differential recruitment of adult-born neurons

EM Amelchenko, DV Bezriadnov… - Journal of …, 2023 - Soc Neuroscience
Exposure to elevated doses of ionizing radiation, such as those in therapeutic procedures,
catastrophic accidents, or space exploration, increases the risk of cognitive dysfunction. The …

Late maturation of adult-born neurons in the temporal dentate gyrus

JS Snyder, SC Ferrante, HA Cameron - PloS one, 2012 - journals.plos.org
Hippocampal function varies along its septotemporal axis, with the septal (dorsal) pole more
frequently involved in spatial learning and memory and the temporal (ventral) pole playing a …

Differential effects of stress and glucocorticoids on adult neurogenesis

TJ Schoenfeld, E Gould - Neurogenesis and neural plasticity, 2013 - Springer
Stress is known to inhibit neuronal growth in the hippocampus. In addition to reducing the
size and complexity of the dendritic tree, stress and elevated glucocorticoid levels are known …

Early survival and delayed death of developmentally‐born dentate gyrus neurons

SP Cahill, RQ Yu, D Green, EV Todorova… - …, 2017 - Wiley Online Library
The storage and persistence of memories depends on plasticity in the hippocampus. Adult
neurogenesis produces new neurons that mature through critical periods for plasticity and …

Immediate-early genes modulation by antipsychotics: translational implications for a putative gateway to drug-induced long-term brain changes

A De Bartolomeis, EF Buonaguro, G Latte… - Frontiers in behavioral …, 2017 - frontiersin.org
An increasing amount of research aims at recognizing the molecular mechanisms involved
in long-lasting brain architectural changes induced by antipsychotic treatments. Although …