Psychotropic drugs acting on monoamine neurotransmission are major pharmacological
treatments for neuropsychiatric conditions such as schizophrenia, depression, bipolar …

Clinicians have long used lithium to treat manic depression. They have also observed that
lithium causes granulocytosis and lymphopenia while it enhances immunological activities …

Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have
met with limited success. We sought to increase statistical power to detect disease loci by …

Mental illnesses, such as bipolar disorder, attention-deficit/hyperactivity disorder, depression
and schizophrenia are a major public health concern worldwide. Several pharmacologic …

Dopamine D2 receptor antagonism is a unifying property of all antipsychotic drugs in clinical
use. Remarkably, the effector molecules through which these medications exert their actions …

During development of the central nervous system the Wnt signaling pathway has been
implicated in a wide spectrum of physiological processes, including neuronal connectivity …

Schizophrenia-related psychosis is associated with disturbances in mesolimbic dopamine
(DA) transmission, characterized by hyperdopaminergic activity in the mesolimbic pathway …

Background Genetic factors play a major role in the risk for neurodevelopmental disorders
such as autism spectrum disorders (ASDs) and intellectual disability (ID). The underlying …

Brain dopamine receptors have been preferred targets for numerous pharmacological
compounds developed for the treatment of various neuropsychiatric disorders. Recent …

Wnt signaling is a key pathway that helps organize development of the nervous system. It
influences cell proliferation, cell fate, and cell migration in the developing nervous system …