Revisiting the safety of aspartame

AK Choudhary, E Pretorius - Nutrition reviews, 2017 - academic.oup.com
Aspartame is a synthetic dipeptide artificial sweetener, frequently used in foods,
medications, and beverages, notably carbonated and powdered soft drinks. Since 1981 …

[PDF][PDF] Nephrotoxic effect of aspartame as an artificial sweetener: A brief review

MR Ardalan, H Tabibi, VE Attari… - Iranian journal of kidney …, 2017 - researchgate.net
Artificial sweeteners are a class of food additives that provide sweet taste without increasing
caloric intake. They are also named as 'nonnutritive sweeteners,''high-intensity …

Can artificial sweeteners increase the risk of cancer incidence and mortality: evidence from prospective studies

S Yan, F Yan, L Liu, B Li, S Liu, W Cui - Nutrients, 2022 - mdpi.com
Cancer has become a major challenge in the global disease burden. Artificial sweeteners
are a class of chemical compounds that are used as food and beverage addition agent to …

Self-assembly of artificial sweetener aspartame yields amyloid-like cytotoxic nanostructures

BG Anand, KP Prajapati, K Dubey, N Ahamad… - ACS …, 2019 - ACS Publications
Recent reports have revealed the intrinsic propensity of single aromatic metabolites to
undergo self-assembly and form nanostructures of amyloid nature. Hence, identifying …

[HTML][HTML] Aspartame: A review of genotoxicity data

D Kirkland, D Gatehouse - Food and Chemical Toxicology, 2015 - Elsevier
Aspartame is a methyl ester of a dipeptide of aspartic acid and phenylalanine. It is 200×
sweeter than sucrose and is approved for use in food products in more than 90 countries …

[HTML][HTML] Smart electrochemical immunosensor for detection of aspartame in dietary products supported by in silico methods

P Hloma, GE Uwaya, K Bisetty - Biosensors and Bioelectronics: X, 2022 - Elsevier
Aspartame (ASP) is one of the most widely used artificial sweeteners; therefore, there is a
need to develop reliable and reproducible analytical methods for its detection. In this study …

Association between consumption of artificial sweeteners and breast cancer risk: a systematic review and meta-analysis of observational studies

X Ye, Y Zhang, Y He, M Sheng, J Huang… - Nutrition and …, 2023 - Taylor & Francis
This study intends to conduct a meta-analysis based on existing research results to further
investigate their relationship between artificial sweetener exposure and breast cancer risk …

Intake of artificial sweeteners among adults is associated with reduced odds of gastrointestinal luminal cancers: a meta-analysis of cohort and case-control studies

A Tepler, G Hoffman, S Jindal, N Narula, SC Shah - Nutrition Research, 2021 - Elsevier
The association between artificial sweetener (AS) consumption and the risk of organ-specific
cancers has been debated for decades. We hypothesized that AS consumption is …

[HTML][HTML] Mutagenicity and genotoxicity studies of aspartame

A Otabe, F Ohta, A Takumi, B Lynch - Regulatory Toxicology and …, 2019 - Elsevier
Two studies were conducted to further assess its mutagenic and genotoxic potential. In a
bacterial reverse mutation pre-incubation study, Salmonella typhimurium strains TA100 …

Assessment of the carcinogenic potential of high intense-sweeteners through the test for detection of epithelial tumor clones (warts) in Drosophila melanogaster

MA Vasconcelos, PC Orsolin, RG Silva-Oliveira… - Food and Chemical …, 2017 - Elsevier
High intensity-sweeteners (HIS) are natural or synthetic substances, sweeter than sugar,
providing sweetness without calories. Sweeteners are mainly used as an aid in losing …