Archaea often thrive in environmental extremes, enduring levels of heat, pressure, salinity,
pH, and radiation that prove intolerable to most life. Many environmental extremes raise the …

Recently, a novel gene-deletion method was developed for the crenarchaeal model
Sulfolobus islandicus, which is a suitable tool for addressing gene essentiality in depth …

Summary The Mre11/Rad50 complex has been implicated in the early steps of DNA double-
strand break (DSB) repair through homologous recombination in several organisms …

Archaea, like bacteria and eukaryotes, contain proteins involved in various mechanisms of
DNA repair, highlighting the importance of these processes for all forms of life. Species of …

Tailed double-stranded DNA viruses (order Caudovirales) represent the dominant
morphotype among viruses infecting bacteria. Analysis and comparison of complete …

Organisms living in extreme environments must cope with large fluctuations of temperature,
high levels of radiation and/or desiccation, conditions that can induce DNA damage ranging …

Archaea adjust the number of cyclopentane rings in their glycerol dibiphytanyl glycerol
tetraether (GDGT) membrane lipids as a homeostatic response to environmental stressors …

Archaeal NurA protein plays a key role in producing 3′-single stranded DNA used for
homologous recombination repair, together with HerA, Mre11, and Rad50. Herein, we …

Although hyperthermophilic archaea arguably have a great need for efficient DNA repair,
they lack members of several DNA repair protein families broadly conserved among bacteria …

Abstract The HerA ATPase cooperates with the NurA nuclease and the Mre11–Rad50
complex for the repair of double-strand DNA breaks in thermophilic archaea. Here we …