The concept of an ideal antibiotic: implications for drug design

M Gajdács - Molecules, 2019 - mdpi.com
The emergence and spread of antibiotic-resistant pathogens is a major public health issue,
which requires global action of an intersectoral nature. Multidrug-resistant (MDR) pathogens …

Antibiotic combination therapy against resistant bacterial infections: synergy, rejuvenation and resistance reduction

ARM Coates, Y Hu, J Holt, P Yeh - Expert review of Anti-infective …, 2020 - Taylor & Francis
ABSTRACT Introduction: Anti-Microbial Resistance (AMR) is a pandemic which threatens
modern medicine. There is a lack of effective drug treatment due to the slow pace, high cost …

HRG-9 homologues regulate haem trafficking from haem-enriched compartments

F Sun, Z Zhao, MM Willoughby, S Shen, Y Zhou… - Nature, 2022 - nature.com
Haem is an iron-containing tetrapyrrole that is critical for a variety of cellular and
physiological processes,–. Haem binding proteins are present in almost all cellular …

The struggle to end a millennia-long pandemic: novel candidate and repurposed drugs for the treatment of tuberculosis

BD Edwards, SK Field - Drugs, 2022 - Springer
This article provides an encompassing review of the current pipeline of putative and
developed treatments for tuberculosis, including multidrug-resistant strains. The review has …

Hydrothermal synthesize of HF-free MIL-100 (Fe) for isoniazid-drug delivery

MA Simon, E Anggraeni, FE Soetaredjo, SP Santoso… - Scientific reports, 2019 - nature.com
Sustainable development of drug delivery materials with good biocompatibility and
controlled-release is a popular topic among researchers. In this research study, we …

An overview of DNA-encoded libraries: A versatile tool for drug discovery

D Madsen, C Azevedo, I Micco, LK Petersen… - Progress in medicinal …, 2020 - Elsevier
DNA-encoded libraries (DELs) are collections of small molecules covalently attached to
amplifiable DNA tags carrying unique information about the structure of each library …

Comprehensive review on mechanism of action, resistance and evolution of antimycobacterial drugs

A Chauhan, M Kumar, A Kumar, K Kanchan - Life sciences, 2021 - Elsevier
Tuberculosis is one of the deadliest infectious diseases existing in the world since ancient
times and still possesses serious threat across the globe. Each year the number of cases …

[HTML][HTML] Tuberculosis of the spine

W Leowattana, P Leowattana… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Pott's spine, commonly known as spinal tuberculosis (TB), is an extrapulmonary form of TB
caused by Mycobacterium TB. Pott's paraplegia occurs when the spine is involved. Spinal …

[PDF][PDF] Vitamin B6 addiction in acute myeloid leukemia

CC Chen, B Li, SE Millman, C Chen, X Li, JP Morris… - Cancer Cell, 2020 - cell.com
Cancer cells rely on altered metabolism to support abnormal proliferation. We performed a
CRISPR/Cas9 functional genomic screen targeting metabolic enzymes and identified PDXK …

Targeting mycobacterial membranes and membrane proteins: Progress and limitations

G Kumar, S Kapoor - Bioorganic & Medicinal Chemistry, 2023 - Elsevier
Among the various bacterial infections, tuberculosis continues to hold center stage. Its
causative agent, Mycobacterium tuberculosis, possesses robust defense mechanisms …