Background Gastric cancer (GC) is one of the most common cancers in Iran. Knowledge of
the epidemiology of the disease is essential in planning for prevention. So this study aimed …

Cancer progression is driven by an accumulation of numerous genetic and epigenetic
alterations in cancer cells themselves as well as constructional changes in their …

Abstract Astrocyte elevated gene-1 (AEG-1), also known as metadherin (MTDH) and lysine-
rich CEACAM1 coisolated (LYRIC), was initially cloned in 2002. AEG-1/MTDH/LYRIC has …

Abstract “Gain-of-function” and “loss-of-function” studies in human cancer cells and analysis
of a transgenic mouse model have convincingly established that AEG-1/MTDH/LYRIC …

Abstract Metadherin (AEG-1/MTDH/LYRIC) is a 582-amino acid transmembrane protein,
encoded by a gene located at chromosome 8q22, and distributed throughout the cytoplasm …

Since its initial cloning in 2002, a plethora of studies in a vast number of cancer indications,
has strongly established AEG-1 as a bona fide oncogene. In all types of cancer cells …

Tumor development is initiated by an accumulation of numerous genetic and epigenetic
alterations that promote tumor initiation, invasion and metastasis. Astrocyte elevated gene‑1 …

Recent studies of the human transcriptome, most prominently by the ENCyclopedia Of DNA
Elements project, have revealed an unexpected number of noncoding RNAs (ncRNAs) …

As the second most frequent cause of cancer death, gastric cancer is a common disease
worldwide. Most of the patients are being diagnosed in the stage that conventional …

Background: Gastric cancer is the second and fourth most common cancer in Iranian men
and women, respectively, but it is the first leading cause of cancer deaths in Iran. Most …