Critical care, like many healthcare areas, is under a dual assault from significantly
increasing demographic and economic pressures. Intensive care unit (ICU) patients are …

Life science researchers use computational models to articulate and test hypotheses about
the behavior of biological systems. Semantic annotation is a critical component for …

Objective: To develop quantitative methods for the clinical interpretation of the
ballistocardiogram (BCG). Methods: A closed-loop mathematical model of the …

The flapping coupling between two filaments is studied theoretically and experimentally in
this paper. A temporal linear instability analysis is carried out based on a simplified …

In several crucial applications, domain knowledge is encoded by a system of ordinary
differential equations (ODE), often stemming from underlying physical and biological …

Critically ill patients are highly variable in their response to care and treatment. This
variability and the search for improved outcomes have led to a significant increase in the use …

To phenotype mechanistic differences between heart failure with reduced (HFrEF) and
preserved (HFpEF) ejection fraction, a closed‐loop model of the cardiovascular system …

Mathematical models are essential tools to study how the cardiovascular system maintains
homeostasis. The utility of such models is limited by the accuracy of their predictions, which …

Physics-based models can be applied to describe mechanisms in both health and disease,
which has the potential to accelerate the development of personalized medicine. The aim of …

Current mathematical models of the cardiovascular system that are based on systems of
ordinary differential equations are limited in their ability to mimic important features of …