Ultraviolet B (UVB), in addition to having carcinogenic activity, is required for the production
of vitamin D3 (D3) in the skin which supplies> 90% of the body's requirement. Vitamin D is …

Context: There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides
their well-known calcium-related functions, may also exert antiproliferative, pro …

Melanoma is one of the most lethal types of skin cancer, with a poor prognosis once the
disease enters metastasis. The efficacy of currently available treatment schemes for …

Recent findings suggest that part of the anti-tumor effects of several chemotherapeutic
agents require an intact immune system. This is in part due to the induction of immunogenic …

Background Active vitamin D analogs that are less toxic than calcitriol can be useful in the
combined treatment of patients suffering from colon cancer. In the present study we …

Aim: The aim of this study was the evaluation of the antitumor effect of two synthetic analogs
of vitamin D, PRI-2191 and PRI-2205 in combined treatment with irinotecan or oxaliplatin on …

Although the skin production of vitamin D is initiated by ultraviolet radiation type B (UVB), the
role vitamin D plays in antioxidative or pro-oxidative responses remains to be elucidated …

In the present study, we evaluated the antitumor effect of two synthetic analogs of vitamin D,
namely PRI-2191 [(24R)-1, 24-dihydroxyvitamin D3] and PRI-2205 (5, 6-trans calcipotriol), in …

Deregulated melanogenesis is involved in melanomagenesis and melanoma progression
and resistance to therapy. Vitamin D analogs have anti-melanoma activity. While the …

Vitamin D is a precursor for secosteroidal hormones, which demonstrate pleiotropic
biological activities, including the regulation of growth and the differentiation of normal and …