Gliomas are the most common primary intracranial tumor, representing 81% of malignant
brain tumors. Although relatively rare, they cause significant mortality and morbidity …

Gliomas are a heterogeneous group of brain tumors with distinct biological and clinical
properties. Despite advances in surgical techniques and clinical regimens, treatment of high …

Therapy development for adult diffuse glioma is hindered by incomplete knowledge of
somatic glioma driving alterations and suboptimal disease classification. We defined the …

Glioblastoma is the most common and most aggressive diffuse glioma, associated with short
survival and uniformly fatal outcome, irrespective of treatment. It is characterized by …

Glioma diagnosis is based on histomorphology and grading; however, such classification
does not have predictive clinical outcome after glioblastomas have developed. To date, no …

Background Genetic and epigenetic profiling of glioblastomas has provided a
comprehensive list of altered cancer genes of which only O6-methylguanine …

The outcome of patients with anaplastic gliomas varies considerably. Whether a molecular
classification of anaplastic gliomas based on large-scale genomic or epigenomic analyses …

Diffusely infiltrating astrocytomas include diffuse astrocytomas WHO grade II and anaplastic
astrocytomas WHO grade III and are classified under astrocytic tumours according to the …

Low-grade diffuse gliomas are a heterogeneous group of primary glial brain tumors with
highly variable survival. Currently, patients with low-grade diffuse gliomas are stratified into …

Diffuse high-grade gliomas contain some of the most dangerous human cancers that lack
curative treatment options. The recent molecular stratification of gliomas by the World Health …