[HTML][HTML] Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations
Genome-wide association studies (GWASs) have focused primarily on populations of
European descent, but it is essential that diverse populations become better represented …
European descent, but it is essential that diverse populations become better represented …
Use of race, ethnicity, and ancestry data in health research
C Lu, R Ahmed, A Lamri, SS Anand - PLOS Global Public Health, 2022 - journals.plos.org
Race, ethnicity, and ancestry are common classification variables used in health research.
However, there has been no formal agreement on the definitions of these terms, resulting in …
However, there has been no formal agreement on the definitions of these terms, resulting in …
Proteomic profiling platforms head to head: leveraging genetics and clinical traits to compare aptamer-and antibody-based methods
High-throughput proteomic profiling using antibody or aptamer-based affinity reagents is
used increasingly in human studies. However, direct analyses to address the relative …
used increasingly in human studies. However, direct analyses to address the relative …
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
Abstract The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate
the genetic architecture and biology of heart, lung, blood and sleep disorders, with the …
the genetic architecture and biology of heart, lung, blood and sleep disorders, with the …
Genetic analyses of diverse populations improves discovery for complex traits
Genome-wide association studies (GWAS) have laid the foundation for investigations into
the biology of complex traits, drug development and clinical guidelines. However, the …
the biology of complex traits, drug development and clinical guidelines. However, the …
Genetic association testing using the GENESIS R/Bioconductor package
Abstract Summary The Genomic Data Storage (GDS) format provides efficient storage and
retrieval of genotypes measured by microarrays and sequencing. We developed GENESIS …
retrieval of genotypes measured by microarrays and sequencing. We developed GENESIS …
Environment dominates over host genetics in shaping human gut microbiota
Human gut microbiome composition is shaped by multiple factors but the relative
contribution of host genetics remains elusive. Here we examine genotype and microbiome …
contribution of host genetics remains elusive. Here we examine genotype and microbiome …
Mexican Biobank advances population and medical genomics of diverse ancestries
Latin America continues to be severely underrepresented in genomics research, and fine-
scale genetic histories and complex trait architectures remain hidden owing to insufficient …
scale genetic histories and complex trait architectures remain hidden owing to insufficient …
Model-free estimation of recent genetic relatedness
MP Conomos, AP Reiner, BS Weir… - The American Journal of …, 2016 - cell.com
Genealogical inference from genetic data is essential for a variety of applications in human
genetics. In genome-wide and sequencing association studies, for example, accurate …
genetics. In genome-wide and sequencing association studies, for example, accurate …
[HTML][HTML] Harmonizing genetic ancestry and self-identified race/ethnicity in genome-wide association studies
Large-scale multi-ethnic cohorts offer unprecedented opportunities to elucidate the genetic
factors influencing complex traits related to health and disease among minority populations …
factors influencing complex traits related to health and disease among minority populations …