Predictors of death in patients with neonatal sepsis in a Peruvian hospital

D Vizcarra-Jiménez, C Copaja-Corzo… - Tropical Medicine and …, 2022 - mdpi.com
Reducing neonatal mortality is a global challenge. This study's objective was to determine
the predictors of mortality in patients with neonatal sepsis. The study was a retrospective …

Targeting the Toll-like receptor pathway as a therapeutic strategy for neonatal infection

ML Dias, KM O'Connor, EM Dempsey… - American Journal …, 2021 - journals.physiology.org
Toll-like receptors (TLRs) are crucial transmembrane receptors that form part of the innate
immune response. They play a role in the recognition of various microorganisms and their …

Probiotics for Preterm Infants—Update 2024

M Deshmukh, S Patole - Current Treatment Options in Pediatrics, 2024 - Springer
Purpose of review Necrotising enterocolitis (NEC) continues to be associated with high
mortality and morbidity in preterm neonates despite recent advances in neonatal care …

Role of central endpoint adjudication and challenges in trials on neonatal sepsis—a case of ProSPoNS trial

AP Sinha, D Raja, KS Mahajan, P Sharma, SS Gupta… - Trials, 2024 - Springer
Despite progress in reducing the infant mortality in India, the neonatal mortality decline has
been slower, necessitating concerted efforts to achieve Sustainable Development Goal-3. A …

[HTML][HTML] Use of Probiotics for Preventing Necrotizing Enterocolitis in Preterm Infants: A Survey of Current Practices Among Indian Neonatologists

K More, A Hanumantharaju, A Amrit, SM Nimbalkar… - Cureus, 2024 - pmc.ncbi.nlm.nih.gov
Objective: Probiotics are known to reduce the risk of necrotizing enterocolitis (NEC≥ Stage
II) significantly, as well as all-cause mortality, late-onset sepsis (LOS), and feeding …

肠道菌群在脓毒症相关性肝损伤发病与治疗中的作用研究进展

陈文胜, 刘文明 - 中国全科医学, 2024 - chinagp.net
脓毒症的特点是对感染的免疫反应失调, 导致威胁生命的器官功能障碍. 脓毒症相关性肝损伤(
SALI) 被认为是重症监护室(ICU) 中预测患者死亡的独立危险因素. 随着近年来对肠 …

Research Progress on the Role of Gut Microbiota in the Pathogenesis and Treatment of Sepsis-associated Liver Injury

W CHEN, W LIU - Chinese General Practice, 2024 - chinagp.net
Sepsis is characterized by a dysregulation of immune response to infection, leading to life-
threatening organ dysfunction. Sepsis-associated liver injury (SALI) is considered an …

Compensation in Neonatal Clinical Trials: A Perspective

A Mathur, D Raja, A Sinha, SS Gupta, YK Gupta… - Indian Pediatrics, 2024 - Springer
Well conducted clinical trials are the mainstay for generating evidence on preferred
treatments. In order to adequately protect the interests of the trial participants, the Central …

Challenges in Trials on Neonatal Sepsis-Case of ProSPoNS Trial & Role of Central Endpoint Adjudication

AP Sinha, DK Raja, KS Mahajan, SS Gupta, R Poluru… - 2024 - researchsquare.com
Background: Despite progress in reducing Infant mortality in India, neonatal mortality decline
is slower, necessitating concerted efforts to achieve Sustainable Development Goal-3. A …