Protein production for structural and biophysical studies, functional assays, biomarkers,
mechanistic studies in vitro and in vivo, but also for therapeutic applications in pharma …

Due to the lack of genetically encoded probes for fluorine-19 nuclear magnetic resonance
spectroscopy (19F NMR), its utility for probing eukaryotic membrane protein dynamics is …

The concept of genetic code expansion (GCE) has revolutionized the field of chemical and
synthetic biology, enabling the site-specific incorporation of noncanonical amino acids …

Specific arrestin conformations are coupled to distinct downstream effectors, which underlie
the functions of many G-protein-coupled receptors (GPCRs). Here, using unnatural amino …

Abstract Characterization of the dynamic conformational changes in membrane protein
signaling complexes by nuclear magnetic resonance (NMR) spectroscopy remains …

Fluorine labelling represents one promising approach to study proteins in their native
environment due to efficient suppressing of background signals. Here, we systematically …

l-Tyrosine derivatives were obtained in> 97% ee via a biocatalytic one-pot two-step cascade
using substituted benzenes, pyruvate, and NH3 as starting materials. In the first step …

Exciting new technological developments have pushed the boundaries of structural biology,
and have enabled studies of biological macromolecules and assemblies that would have …

Advances in acetylated protein–protein/DNA interactions depend on the development of a
novel NMR (nuclear magnetic resonance) probe to study the conformational changes of …

Phosphotyrosine-containing compounds attract significant attention due to their potential to
modulate signalling pathways by binding to phospho-writers, erasers and readers such as …