Toll-like receptor signaling and its role in cell-mediated immunity
Innate immunity is the first defense system against invading pathogens. Toll-like receptors
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
[HTML][HTML] RIG-I-like receptors: their regulation and roles in RNA sensing
J Rehwinkel, MU Gack - Nature Reviews Immunology, 2020 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus
infection, mediating the transcriptional induction of type I interferons and other genes that …
infection, mediating the transcriptional induction of type I interferons and other genes that …
SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy
X Li, P Hou, W Ma, X Wang, H Wang, Z Yu… - Cellular & molecular …, 2022 - nature.com
The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused severe morbidity and …
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused severe morbidity and …
An update on the effects of vitamin D on the immune system and autoimmune diseases
Vitamin D intervenes in calcium and phosphate metabolism and bone homeostasis.
Experimental studies have shown that 1, 25-dihydroxyvitamin D (calcitriol) generates …
Experimental studies have shown that 1, 25-dihydroxyvitamin D (calcitriol) generates …
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity
Activation of the RIG-I-like receptors, retinoic-acid inducible gene I (RIG-I) and melanoma
differentiation-associated protein 5 (MDA5), establishes an antiviral state by upregulating …
differentiation-associated protein 5 (MDA5), establishes an antiviral state by upregulating …
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors
K Onomoto, K Onoguchi, M Yoneyama - Cellular & molecular …, 2021 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
ISG15 in antiviral immunity and beyond
YC Perng, DJ Lenschow - Nature Reviews Microbiology, 2018 - nature.com
The host response to viral infection includes the induction of type I interferons and the
subsequent upregulation of hundreds of interferon-stimulated genes. Ubiquitin-like protein …
subsequent upregulation of hundreds of interferon-stimulated genes. Ubiquitin-like protein …
Comparative structure and function analysis of the RIG-I-like receptors: RIG-I and MDA5
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
Genetics of the human microglia regulome refines Alzheimer's disease risk loci
Microglia are brain myeloid cells that play a critical role in neuroimmunity and the etiology of
Alzheimer's disease (AD), yet our understanding of how the genetic regulatory landscape …
Alzheimer's disease (AD), yet our understanding of how the genetic regulatory landscape …
Opposing roles of type I interferons in cancer immunity
GM Boukhaled, S Harding… - Annual Review of …, 2021 - annualreviews.org
The immune system is tasked with identifying malignant cells to eliminate or prevent cancer
spread. This involves a complex orchestration of many immune cell types that together …
spread. This involves a complex orchestration of many immune cell types that together …