Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …

Pluripotent stem cells of the mammalian epiblast and their cultured counterparts—embryonic
stem cells (ESCs) and epiblast stem cells (EpiSCs)—have the capacity to differentiate in all …

Oct4 is essential to maintain pluripotency and has a pivotal role in establishing the germline.
Its DNA-binding POU domain was recently found to bind motifs with methylated CpG …

The transcription factor Oct1/Pou2f1 promotes poised gene expression states, mitotic
stability, glycolytic metabolism and other characteristics of stem cell potency. To determine …

The histone chaperone facilitates chromatin transactions (FACT) is associated with nuclear
processes, including DNA transcription, replication, and repair. We previously showed that …

Human pluripotent stem cells hold significant promise for regenerative medicine. However,
long differentiation protocols and immature characteristics of stem cell-derived cell types …

Drosophila POU/Oct transcription factors are required for many developmental processes,
but their putative regulation of adult stem cell activity has not been investigated. Here, we …

The ability of a virus to infect a cell type is at least in part determined by the presence of host
factors required for the viral life cycle. However, even within cell types that express known …

Abstract Oct-1 (POU2F1) is a DNA-binding transcription regulator and its level being highly
increased in many human cancers. Oct-1 is present in the human cells as a family of …

The emergence of new primate-specific genes is an essential factor in human and primate
brain development and functioning. POU2F1/Oct-1 is a transcription regulator in higher …