Specific chemical modifications of biological molecules are an efficient way of regulating
molecular function, and a plethora of downstream signalling pathways are influenced by the …

Wilms tumour (WT) is a childhood embryonal tumour that is paradigmatic of the intersection
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …

In the 30 years since the first report of parental imprinting in insulin-like growth factor 2 (Igf2)
knockout mouse models, we have learnt much about the structure of this protein, its role and …

The numerous quality control pathways that target defective ribonucleic acids (RNAs) for
degradation play key roles in shaping mammalian transcriptomes and preventing disease …

MicroRNAs (miRNAs) associated with Argonaute proteins (AGOs) regulate gene expression
in mammals. miRNA 3'ends are subject to frequent sequence modifications, which have …

Congenital anomalies of the kidney and urinary tract (CAKUT) are common birth defects
derived from abnormalities in renal differentiation during embryogenesis. CAKUT is the …

Multiple RNA pathways are required to produce functional sperm. Here, we review RNA post-
transcriptional regulation during spermatogenesis with particular emphasis on the role of …

Currently, for seemingly every type of cancer, dysregulated levels of non-coding RNAs
(ncRNAs) are reported and non-coding transcripts are expected to be the next class of …

Since previous consensus-based Wilms tumour (WT) surveillance guidelines were
published, novel genes and syndromes associated with WT risk have been identified, and …

In humans and in mice the formation of nephrons during embryonic development reaches
completion near the end of gestation, after which no new nephrons are formed. The final …