Human UDP-glucuronosyltransferase (UGT) exists as a superfamily of 22 proteins, which
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …

Clinicians understand that individual patients differ in their response to specific opioid
analgesics and that patients may require trials of several opioids before finding an agent that …

UDP-glucuronosyltransferase (UGT) enzymes catalyze the conjugation of various
endogenous substances (eg, bilirubin) and exogenous compounds (eg, drugs). The human …

Ethnicity is one factor that may account for the observed differences in both
pharmacokinetics (PK) and pharmacodynamics (PD) of drugs, resulting in variability in …

ABSTRACT UDP-glucuronosyltransferase (UGT) enzymes comprise a superfamily of key
proteins that catalyze the glucuronidation reaction on a wide range of structurally diverse …

Clinical studies comparing the response and side effects of various opioids have not been
able to show robust differences between drugs. Hence, recommendations of the regulatory …

Background Adjuvant tamoxifen therapy substantially decreases the risk of recurrence and
mortality in women with hormone (estrogen and/or progesterone) receptor–positive breast …

Background & Aims: Diclofenac is a widely used nonsteroidal anti-inflammatory drug and is
among the most common drugs causing idiosyncratic hepatotoxicity in several recent series …

Opioids are used for acute and chronic pain and dependency. They have a narrow
therapeutic index and large interpatient variability in response. Genetic factors regulating …

A large number of women receive codeine for obstetric pain while breastfeeding. Following
a case of fatal opioid poisoning in a breastfed neonate whose codeine prescribed mother …