Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

To perform their functions, the kidneys maintain stable blood perfusion in the face of
fluctuations in systemic BP. This is done through autoregulation of blood flow by the generic …

This review outlines the features of tandem regulation of glomerular microcirculation by
autoregulatory mechanisms and intraglomerular redistribution of blood flow. Multiple points …

Introduction: Tubuloglomerular feedback (TGF) is the negative feedback component of renal
blood flow (RBF) autoregulation. Neighbouring nephrons often exhibit spontaneous TGF …

The kidneys tightly control the composition of our internal environment to maintain
homeostasis in the face of external variability. The regulation of blood volume begins in the …

Connexins, assembled as a hexameric connexon, form a transmembrane hemichannel that
provides a conduit for paracrine signalling of small molecules and ions to regulate the …

The ability of cells to communicate and synchronise their activity is essential for the
maintenance of tissue structure, integrity and function. A family of membrane‐bound proteins …

Genetic loss-of-function defects of connexin 40 in renal juxtaglomerular cells are associated
with renin-dependent hypertension. The dysregulation of renin secretion results from an …

Connexin (Cx) 37, 40, and 43 are implicated in vascular function, specifically in the electrical
coupling of endothelial cells and vascular smooth-muscle cells. In the present study, we …

Background: Klotho interacts with various membrane proteins, such as transforming growth
factor-β (TGFβ) and insulin-like growth factor (IGF) receptors. The renal expression of klotho …