Multiple sclerosis (MS) is an often disabling disease primarily affecting young adults that
exhibits extraordinary clinical, radiological, and pathological heterogeneity. We review the …

Oligodendrocytes (OLs) are the myelinating cells of the central nervous system (CNS) during
development and throughout adulthood. They result from a complex and well controlled …

Serial monthly magenetization transfer (MT) imaging was performed to evaluate whether a
change of the normal appearing white matter (NAWM), which precedes the appearance of …

The idea that the initiating event in the formation of all new multiple sclerosis lesions is a
focal blood–brain barrier (BBB) leakage associated with perivascular inflammation has been …

Objective: To test the specificity for demyelination of a new neuroimaging sign: contrast
enhancement shaped as an open ring or a crescent circumscribed to the white matter …

An exploratory, prospective, open‐label study of fumaric acid esters (FAE, Fumaderm®) was
conducted in patients with relapsing–remitting multiple sclerosis (RRMS). The study …

Background: There are no published MRI studies comparing interferon beta 1b (IFNβ-1b)
and glatiramer acetate (GA) for treatment of relapsing multiple sclerosis (MS). Objective: To …

Leakage of the blood–brain barrier (BBB) is a common pathological feature in multiple
sclerosis (MS). Following a breach of the BBB, albumin, the most abundant protein in …

Epithelial and endothelial tight junctions are pathologically altered in infectious,
inflammatory, neoplastic and other diseases. Previously, we described such abnormalities …

Background and Purpose: The quantification of cerebral blood flow (CBF), cerebral blood
volume (CBV), and blood-brain barrier permeability in scattered lesions in the brain is a …