The endothelium is composed of a monolayer of endothelial cells, lining the interior surface
of blood and lymphatic vessels. Endothelial cells display important homeostatic functions …

Endothelial dysfunction is characterized by nitric oxide dysregulation and an altered redox
state. Oxidative stress and inflammatory markers prevail, thus promoting atherogenesis and …

Background A reduction in number and function of endothelial progenitor cells (EPCs)
occurs in both physiologic aging and chronic heart failure (CHF). We assessed whether …

Although the burden of heart failure with preserved ejection fraction (HFpEF) is increasing,
there is no therapy available that improves prognosis. Clinical trials using beta blockers and …

Aim The endothelium, mainly via nitric oxide (NO) release, adjusts the coronary flow.
Cardiac function is closely linked to blood flow; thus, we tested the hypothesis that NO …

Endothelial dysfunction is an early abnormality in the process of atherosclerosis and
cardiovascular disease and has been associated with worse clinical outcome. Cardiac …

Exercise training (ET) has emerged as a nonpharmacological therapy for cardiovascular
diseases because of its helpful milieu for improving vascular function. The aim of the present …

Myocardial perfusion imaging with 15O-water positron emission tomography (PET) is a
validated tool for quantitative measurement of myocardial blood flow (MBF) and myocardial …

Background Endothelial dysfunction is a key mechanism in the development of cardiac
remodelling and diastolic dysfunction in heart failure with preserved ejection fraction …

Endothelial dysfunction is a strong prognostic factor in predicting the development of
cardiovascular diseases. Dysfunctional endothelium loses its homeostatic ability to regulate …