Post-translational modifications of DNA and histones are epigenetic mechanisms, which
affect the chromatin structure, ultimately leading to gene expression changes. A number of …

Despite significant advances made in epigenetic research in recent decades, many
questions remain unresolved, especially concerning cause and consequence of epigenetic …

Rhabdomyosarcoma (RMS) is a mesenchymal malignancy composed of neoplastic primitive
precursor cells that exhibit histological features of myogenic differentiation. Despite intensive …

EZR, a member of the ezrin-radixin-moesin (ERM) family, is involved in multiple aspects of
cell migration and cancer. SMYD3, a histone H3–lysine 4 (H3–K4)-specific …

Ezrin is the cytoskeletal organizer and functions in the modulation of membrane–
cytoskeleton interaction, maintenance of cell shape and structure, and regulation of cell–cell …

Cancer metastasis is the primary cause of morbidity and mortality in cancer as it remains the
most complicated, devastating, and enigmatic aspect of cancer. Several decades of …

One of the hallmarks of cancer is aberrant DNA methylation, which is associated with
abnormal gene expression. Both hypermethylation and silencing of tumour suppressor …

Concerns over the cost and destructive nature of dental treatment have led to the call for
novel minimally invasive, biologically based restorative solutions. For patients with …

The human epidermal growth factor receptor-2 (HER2/neu/ERBB2) is overexpressed in
several cancer types. Although therapies targeting the HER2/neu protein result in inhibition …

C13ORF18 is frequently hypermethylated in cervical cancer but not in normal cervix and
might serve as a biomarker for the early detection of cervical cancer in scrapings. As …