There is much experimental evidence for the existence of biomechanical constraints which
simplify the problem of control of multi‐segment movements. In addition, it has been …

Recent discoveries about how the central nervous system responds to injury and how
patients reacquire lost behaviours by training have yielded promising new therapies for …

Non‐patterned electrical stimulation of the posterior structures of the lumbar spinal cord in
subjects with complete, long‐standing spinal cord injury, can induce patterned, locomotor …

In the last years it has become possible to regain some locomotor activity in patients
suffering from an incomplete spinal cord injury (SCI) through intense training on a treadmill …

Many individuals with spinal cord injury (SCI) do not regain their ability to walk, even though
it is a primary goal of rehabilitation. Mammals with thoracic spinal cord transection can …

Advances in our understanding of movement control allow us to define more precisely the
requirements for the rehabilitation of patients with movement disorders. Most purposeful …

Harkema, Susan J., Seanna L. Hurley, Uday K. Patel, Philip S. Requejo, Bruce H. Dobkin,
and V. Reggie Edgerton. Human lumbosacral spinal cord interprets loading during stepping …

It is generally accepted that locomotion in mammals, including humans, is based on the
activity of neuronal circuits within the spinal cord (the central pattern generator, CPG) …

How is load sensed by receptors, and how is this sensory information used to guide
locomotion? Many insights in this domain have evolved from comparative studies since it …

Exercise has been found to impact molecular systems important for maintaining neural
function and plasticity. A characteristic finding for the effects of exercise in the brain and …