Signaling pathways and targeted therapy for myocardial infarction
Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …
Interleukin-6 signaling and anti-interleukin-6 therapeutics in cardiovascular disease
PM Ridker, M Rane - Circulation research, 2021 - Am Heart Assoc
IL (interleukin)-6 is a pivotal cytokine of innate immunity, which enacts a broad set of
physiological functions traditionally associated with host defense, immune cell regulation …
physiological functions traditionally associated with host defense, immune cell regulation …
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
While many diseases of aging have been linked to the immunological system, immune
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction
S Cai, M Zhao, B Zhou, A Yoshii… - The Journal of …, 2023 - Am Soc Clin Investig
Innate immune cells play important roles in tissue injury and repair following acute
myocardial infarction (MI). Although reprogramming of macrophage metabolism has been …
myocardial infarction (MI). Although reprogramming of macrophage metabolism has been …
Myocardial ischemia-reperfusion injury and the influence of inflammation
Acute myocardial infarction is caused by a sudden coronary artery occlusion and leads to
ischemia in the corresponding myocardial territory which generally results in myocardial …
ischemia in the corresponding myocardial territory which generally results in myocardial …
Targeting the NLRP3 inflammasome in cardiovascular diseases
The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …
Reappraising the role of inflammation in heart failure
The observation that heart failure with reduced ejection fraction is associated with elevated
circulating levels of pro-inflammatory cytokines opened a new area of research that has …
circulating levels of pro-inflammatory cytokines opened a new area of research that has …
Inflammatory cytokines and chemokines as therapeutic targets in heart failure
A Hanna, NG Frangogiannis - Cardiovascular Drugs and Therapy, 2020 - Springer
Heart failure exhibits remarkable pathophysiologic heterogeneity. A large body of evidence
suggests that regardless of the underlying etiology, heart failure is associated with induction …
suggests that regardless of the underlying etiology, heart failure is associated with induction …
Interleukin-1 and the inflammasome as therapeutic targets in cardiovascular disease
The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …
Fundamental mechanisms of regulated cell death and implications for heart disease
Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …