There is increasing recognition of the importance of blood–brain barrier (BBB) disruption in
aging, dementia, stroke and multiple sclerosis in addition to more commonly-studied …

Cerebral small vessel disease (cSVD) comprises pathological processes of the small
vessels in the brain that may manifest clinically as stroke, cognitive impairment, dementia, or …

Background Blood–brain barrier (BBB) disruption has been noted in animal models of
Parkinson's disease (PD) and forms the basis of the vascular hypothesis of …

Purpose To investigate whether the blood-brain barrier (BBB) leaks blood-circulating
substances in patients with early forms of Alzheimer disease (AD), and if so, to examine the …

Objective: As blood–brain barrier (BBB) dysfunction may occur in normal aging but may also
play a pivotal role in the pathophysiology of cerebral small vessel disease (cSVD), we used …

Neurovascular dysfunction, including blood–brain barrier (BBB) breakdown and cerebral
blood flow (CBF) dysregulation and reduction, are increasingly recognized to contribute to …

The neurovascular unit, which protects neuronal cells and supplies them with essential
molecules, plays an important role in the pathophysiology of Alzheimer's Disease (AD). The …

There is evidence that subtle breakdown of the blood–brain barrier (BBB) is a
pathophysiological component of several diseases, including cerebral small vessel disease …

Blood-brain barrier (BBB) separates the systemic circulation and the brain, regulating
transport of most molecules to protect the brain microenvironment. Multiple structural and …

Background Blood-brain barrier (BBB) breakdown, as an early biomarker for vascular mild
cognitive impairment (vMCI), has only been validated by a few studies. The aim of this study …