Cystic fibrosis and Pseudomonas aeruginosa: the host-microbe interface

S Malhotra, D Hayes Jr, DJ Wozniak - Clinical microbiology …, 2019 - Am Soc Microbiol
In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

Advances in the microbiology of Stenotrophomonas maltophilia

JS Brooke - Clinical microbiology reviews, 2021 - Am Soc Microbiol
Stenotrophomonas maltophilia is an opportunistic pathogen of significant concern to
susceptible patient populations. This pathogen can cause nosocomial and community …

Impact of elexacaftor/tezacaftor/ivacaftor therapy on the cystic fibrosis airway microbial metagenome

ST Pallenberg, MM Pust, I Rosenboom… - Microbiology …, 2022 - Am Soc Microbiol
The introduction of mutation-specific combination therapy with the cystic fibrosis
transmembrane conductance regulator (CFTR) modulators elexacaftor/tezacaftor/ivacaftor …

Enterococcus faecalis antagonizes Pseudomonas aeruginosa growth in mixed-species interactions

CAZ Tan, LN Lam, G Biukovic, EYC Soh… - Journal of …, 2022 - Am Soc Microbiol
Enterococcus faecalis is often coisolated with Pseudomonas aeruginosa in polymicrobial
biofilm-associated infections of wounds and the urinary tract. As a defense strategy, the host …

Dysregulated signalling pathways in innate immune cells with cystic fibrosis mutations

S Lara-Reyna, J Holbrook, HH Jarosz-Griffiths… - Cellular and Molecular …, 2020 - Springer
Cystic fibrosis (CF) is one of the most common life-limiting recessive genetic disorders in
Caucasians, caused by mutations in the cystic fibrosis transmembrane conductance …

High-resolution longitudinal dynamics of the cystic fibrosis sputum microbiome and metabolome through antibiotic therapy

R Raghuvanshi, K Vasco, Y Vázquez-Baeza, L Jiang… - Msystems, 2020 - Am Soc Microbiol
Microbial diversity in the cystic fibrosis (CF) lung decreases over decades as pathogenic
bacteria such as Pseudomonas aeruginosa take over. The dynamics of the CF microbiome …

Long-term evolution of Burkholderia multivorans during a chronic cystic fibrosis infection reveals shifting forces of selection

IN Silva, PM Santos, MR Santos, JEA Zlosnik… - …, 2016 - Am Soc Microbiol
Burkholderia multivorans is an opportunistic pathogen capable of causing severe disease in
patients with cystic fibrosis (CF). Patients may be chronically infected for years, during which …

Mixed Communities of Mucoid and Nonmucoid Pseudomonas aeruginosa Exhibit Enhanced Resistance to Host Antimicrobials

S Malhotra, DH Limoli, AE English, MR Parsek… - MBio, 2018 - Am Soc Microbiol
Pseudomonas aeruginosa causes chronic pulmonary infections in patients with cystic
fibrosis (CF). P. aeruginosa mucoid conversion, defined by overproduction of the …

Practical Guidance for Clinical Microbiology Laboratories: updated guidance for processing respiratory tract samples from people with cystic fibrosis

L Saiman, V Waters, JJ LiPuma… - Clinical Microbiology …, 2024 - journals.asm.org
This guidance presents recommendations for clinical microbiology laboratories for
processing respiratory samples from people with cystic fibrosis (pwCF). Appropriate …

Ecological succession of polymicrobial communities in the cystic fibrosis airways

RA Khanolkar, ST Clark, PW Wang, DM Hwang… - Msystems, 2020 - Am Soc Microbiol
Antimicrobial therapies against cystic fibrosis (CF) lung infections are largely aimed at the
traditional, well-studied CF pathogens such as Pseudomonas aeruginosa and Burkholderia …