Envelope proteins derived from naturally integrated hepatitis B virus DNA support assembly and release of infectious hepatitis delta virus particles
ABSTRACT A natural subviral agent of human hepatitis B virus (HBV), hepatitis delta virus
(HDV), requires only the envelope proteins from HBV in order to maintain persistent …
(HDV), requires only the envelope proteins from HBV in order to maintain persistent …
The Post-Transcriptional Regulatory Element of Hepatitis B Virus: From Discovery to Therapy
K Mouzannar, A Schauer, TJ Liang - Viruses, 2024 - mdpi.com
The post-transcriptional regulatory element (PRE) is present in all HBV mRNAs and plays a
major role in their stability, nuclear export, and enhancement of viral gene expression …
major role in their stability, nuclear export, and enhancement of viral gene expression …
Hepatitis B virus nuclear export elements: RNA stem-loop α and β, key parts of the HBV post-transcriptional regulatory element
Many viruses contain RNA elements that modulate splicing and/or promote nuclear export of
their RNAs. The RNAs of the major human pathogen, hepatitis B virus (HBV) contain a large …
their RNAs. The RNAs of the major human pathogen, hepatitis B virus (HBV) contain a large …
Support of the infectivity of hepatitis delta virus particles by the envelope proteins of different genotypes of hepatitis B virus
N Freitas, K Abe, C Cunha, S Menne… - Journal of …, 2014 - Am Soc Microbiol
This study examined how the envelope proteins of 25 variants of hepatitis B virus (HBV)
genotypes A to I support hepatitis delta virus (HDV) infectivity. The assembled virions bore …
genotypes A to I support hepatitis delta virus (HDV) infectivity. The assembled virions bore …
The G1613A mutation in the HBV genome affects HBeAg expression and viral replication through altered core promoter activity
Infection of hepatitis B virus (HBV) causes acute and chronic hepatitis and is closely
associated with the development of cirrhosis and hepatocellular carcinoma (HCC) …
associated with the development of cirrhosis and hepatocellular carcinoma (HCC) …
Monoclonal antibodies to various epitopes of hepatitis B surface antigen inhibit hepatitis B virus infection
F Golsaz Shirazi, H Mohammadi… - Journal of …, 2014 - Wiley Online Library
Abstract Background and Aim Antibodies against the “a” determinant of hepatitis B surface
antigen (HBsAg) are able to neutralize circulating hepatitis B virus (HBV) particles and …
antigen (HBsAg) are able to neutralize circulating hepatitis B virus (HBV) particles and …
[HTML][HTML] Prospects for inhibiting the post-transcriptional regulation of gene expression in hepatitis B virus
A Chen, NP T-Thienprasert… - World journal of …, 2014 - ncbi.nlm.nih.gov
There is a continuing need for novel antivirals to treat hepatitis B virus (HBV) infection, as it
remains a major health problem worldwide. Ideally new classes of antivirals would target …
remains a major health problem worldwide. Ideally new classes of antivirals would target …
A rational study for identification of highly effective siRNAs against hepatitis B virus
N Thongthae, S Payungporn, Y Poovorawan… - Experimental and …, 2014 - Elsevier
RNA interference (RNAi) is a powerful gene knockdown technique used for study gene
function. It also potentially provides effective agents for inhibiting infectious and genetic …
function. It also potentially provides effective agents for inhibiting infectious and genetic …
Effects of HBV genetic variability on RNAi strategies
N Panjaworayan, CM Brown - Hepatitis research and treatment, 2011 - Wiley Online Library
RNAi strategies present promising antiviral strategies against HBV. RNAi strategies require
base pairing between short RNAi effectors and targets in the HBV pregenome or other …
base pairing between short RNAi effectors and targets in the HBV pregenome or other …
A conserved RNA structural element within the hepatitis B virus post-transcriptional regulatory element enhance nuclear export of intronless transcripts and repress …
Hepatitis B virus (HBV) infection is a primary cause of hepatocellular carcinoma and liver
cirrhosis worldwide. To develop novel antiviral drugs, a better understanding of HBV gene …
cirrhosis worldwide. To develop novel antiviral drugs, a better understanding of HBV gene …