Questions and (some) answers on reactive astrocytes

C Escartin, O Guillemaud, M Carrillo‐de Sauvage - Glia, 2019 - Wiley Online Library
Astrocytes are key cellular partners for neurons in the central nervous system. Astrocytes
react to virtually all types of pathological alterations in brain homeostasis by significant …

Astrocyte reactivity and reactive astrogliosis: costs and benefits

M Pekny, M Pekna - Physiological reviews, 2014 - journals.physiology.org
Astrocytes are the most abundant cells in the central nervous system (CNS) that provide
nutrients, recycle neurotransmitters, as well as fulfill a wide range of other homeostasis …

Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo

EC Damisah, RA Hill, A Rai, F Chen, CV Rothlin… - Science …, 2020 - science.org
Cell death is prevalent throughout life; however, the coordinated interactions and roles of
phagocytes during corpse removal in the live brain are poorly understood. We developed …

Astrocytes are necessary for blood–brain barrier maintenance in the adult mouse brain

BP Heithoff, KK George, AN Phares, IA Zuidhoek… - Glia, 2021 - Wiley Online Library
In the adult brain, multiple cell types are known to produce factors that regulate blood–brain
barrier (BBB) properties, including astrocytes. Yet several recent studies disputed a role for …

The contribution of astrocytes and microglia to traumatic brain injury

IP Karve, JM Taylor, PJ Crack - British journal of pharmacology, 2016 - Wiley Online Library
Traumatic brain injury (TBI) represents a major cause of death and disability in developed
countries. Brain injuries are highly heterogeneous and can also trigger other neurological …

[HTML][HTML] Reactive gliosis in the pathogenesis of CNS diseases

M Pekny, M Pekna - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2016 - Elsevier
Astrocytes maintain the homeostasis of the central nervous system (CNS) by eg recycling of
neurotransmitters and providing nutrients to neurons. Astrocytes function also as key …

Regional astrocyte allocation regulates CNS synaptogenesis and repair

HH Tsai, H Li, LC Fuentealba, AV Molofsky… - Science, 2012 - science.org
Astrocytes, the most abundant cell population in the central nervous system (CNS), are
essential for normal neurological function. We show that astrocytes are allocated to spatial …

Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation

S Bardehle, M Krüger, F Buggenthin… - Nature …, 2013 - nature.com
Astrocytes are thought to have important roles after brain injury, but their behavior has
largely been inferred from postmortem analysis. To examine the mechanisms that recruit …

Important shapeshifter: mechanisms allowing astrocytes to respond to the changing nervous system during development, injury and disease

J Schiweck, BJ Eickholt, K Murk - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Astrocytes are the most prevalent glial cells in the brain. Historically considered as “merely
supporting” neurons, recent research has shown that astrocytes actively participate in a …

The role of astrocytes in multiple sclerosis progression

J Correale, MF Farez - Frontiers in neurology, 2015 - frontiersin.org
Multiple sclerosis (MS) is an inflammatory disorder causing central nervous system (CNS)
demyelination and axonal injury. Although its etiology remains elusive, several lines of …