Practitioners of ancient societies from the time of Hippocrates and earlier recognized and
treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or …

The acute inflammatory response is host-protective to contain foreign invaders. Many of
today's pharmacopeia that block pro-inflammatory chemical mediators can cause serious …

Several lipoxygenase enzymes and cyclooxygenase-2 stereoselectively convert the
polyunsaturated fatty acids arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid …

A western type diet and lifestyle play an important role in the development of chronic
diseases, yet little insight into the precise cellular and biomolecular mechanisms has …

Docosahexaenoic acid (DHA) is an essential fatty acid that is recognized as a beneficial
dietary constituent and as a source of the anti-inflammatory specialized proresolving …

Airborne pathogens and environmental stimuli evoke immune responses in the lung. It is
critical to health that these responses be controlled to prevent tissue damage and the …

Lipid metabolism plays an important role in many lung functions. Disorders of lipid
metabolism are part of the pathogenesis of chronic obstructive pulmonary disease (COPD) …

The two oxylipins 7S, 14S-dihydroxydocosahexaenoic acid (diHDHA) and 7S, 17S-diHDHA
[resolvin D5 (RvD5)] have been found in macrophages and infectious inflammatory …

Abstract Maresin 1 (MaR1) is an immunoresolvent that governs resolution of acute
inflammation, and its local metabolism in the context of infectious inflammation is of interest …

Atherosclerosis is one of the most important problems of modern medicine as it is the
leading cause of hospitalizations, disability, and mortality. The key role in the development …