Hsp90 is a molecular chaperone that maintains the structural and functional integrity of
various client proteins involved in signaling and many other functions of cancer cells. The …

The cell division cycle 25 (CDC25) phosphatases include CDC25A, CDC25B and CDC25C.
These three molecules are important regulators of several steps in the cell cycle, including …

Dasatinib and radotinib are oral BCR-ABL tyrosine kinase inhibitors that were developed as
drugs for the treatment of chronic myeloid leukemia. We report here that the c-KIT (CD117) …

HSP60 undergoes changes in quantity and distribution in some types of tumors suggesting
a participation of the chaperonin in the mechanism of transformation and cancer …

Simple Summary The activation of wild-type p53 protein in human lymphoma is a promising
therapeutic strategy. A precise interruption of a protein–protein interaction, such as the p53 …

Heat shock proteins (HSPs), most of which are molecular chaperones, are highly conserved
proteins produced by cells under physiological stress or pathological conditions. HSP60 (57 …

The protein p53, known as the “Guardian of the Genome”, plays an important role in
maintaining DNA integrity, providing protection against cancer-promoting mutations …

The sirtuin enzyme family members, SIRT1 and SIRT2, play both tumor-promoting and tumor-
suppressing roles, depending on the context and experimental conditions. Compounds that …

Background The links between the p53/MDM2 pathway and the expression of pro-
oncogenic immune inhibitory receptors in tumor cells are undefined. In this report, we …

MS-based proteomic studies aiming for the discovery of acute myeloid leukemia (AML)
biomarkers require sample processing that can assure an optimal proteome coverage and …