Building and applying quantitative adverse outcome pathway models for chemical hazard and risk assessment
An important goal in toxicology is the development of new ways to increase the speed,
accuracy, and applicability of chemical hazard and risk assessment approaches. A …
accuracy, and applicability of chemical hazard and risk assessment approaches. A …
Three perspectives on the prediction of chemical effects in ecosystems
A Schneeweiss, NPD Juvigny‐Khenafou… - Global Change …, 2023 - Wiley Online Library
The increasing production, use and emission of synthetic chemicals into the environment
represents a major driver of global change. The large number of synthetic chemicals, limited …
represents a major driver of global change. The large number of synthetic chemicals, limited …
Quantification of an adverse outcome pathway network by Bayesian regression and Bayesian network modeling
The adverse outcome pathway (AOP) framework has gained international recognition as a
systematic approach linking mechanistic processes to toxicity endpoints. Nevertheless …
systematic approach linking mechanistic processes to toxicity endpoints. Nevertheless …
[HTML][HTML] Sublethal effect modelling for environmental risk assessment of chemicals: Problem definition, model variants, application and challenges
Bioenergetic models, and specifically dynamic energy budget (DEB) theory, are gathering a
great deal of interest as a tool to predict the effects of realistically variable exposure to …
great deal of interest as a tool to predict the effects of realistically variable exposure to …
Incorporating suborganismal processes into dynamic energy budget models for ecological risk assessment
ABSTRACT A working group at the National Institute for Mathematical and Biological
Synthesis (NIMBioS) explored the feasibility of integrating 2 complementary approaches …
Synthesis (NIMBioS) explored the feasibility of integrating 2 complementary approaches …
Conventional and nano-copper pesticides are equally toxic to the estuarine amphipod Leptocheirus plumulosus
Modern nano-engineered pesticides have great promise for agriculture due to their
extended, low dose release profiles that are intended to increase effectiveness but reduce …
extended, low dose release profiles that are intended to increase effectiveness but reduce …
Application of biomarker tools using bivalve models toward the development of adverse outcome pathways for contaminants of emerging concern
B Khan, KT Ho, RM Burgess - Environmental toxicology and …, 2020 - Wiley Online Library
As contaminant exposures in aquatic ecosystems continue to increase, the need for
streamlining research efforts in environmental toxicology using predictive frameworks also …
streamlining research efforts in environmental toxicology using predictive frameworks also …
Stoichiometric ecotoxicology for a multisubstance world
Nutritional and contaminant stressors influence organismal physiology, trophic interactions,
community structure, and ecosystem-level processes; however, the interactions between …
community structure, and ecosystem-level processes; however, the interactions between …
In silico biomarker analysis of the adverse effects of perfluorooctane sulfonate (PFOS) exposure on the metabolic physiology of embryo-larval zebrafish
Perfluorooctane sulfonate (PFOS) is a ubiquitous pollutant in global aquatic ecosystems with
increasing concern for its toxicity to aquatic wildlife through inadvertent exposures. To …
increasing concern for its toxicity to aquatic wildlife through inadvertent exposures. To …
Regulation of reproductive processes with dynamic energy budgets
Linking organismal‐level processes to underlying suborganismal mechanisms at the
molecular, cellular and organ level constitutes a major challenge for predictive ecological …
molecular, cellular and organ level constitutes a major challenge for predictive ecological …