The MYC proto-oncogene is a gene product that coordinates the transcriptional regulation of
a multitude of genes that are essential to cellular programs required for normal as well as …

The cellular stress response corresponds to the molecular changes that a cell undergoes in
response to various environmental stimuli. It induces drastic changes in the regulation of …

Abstract N 6-methyladenosine (m6A) is an abundant nucleotide modification in mRNA that is
required for the differentiation of mouse embryonic stem cells. However, it remains unknown …

Target occupancy is often insufficient to elicit biological activity, particularly for RNA,
compounded by the longstanding challenges surrounding the molecular recognition of RNA …

Cells respond to stress stimuli through coordinated changes in gene expression. The
regulation of translation is often used under these circumstances because it allows …

▪ Abstract The Myc/Max/Mad network comprises a group of transcription factors whose
distinct interactions result in gene-specific transcriptional activation or repression. A great …

The human genome encodes tens of thousands circular RNAs (circRNAs) with mostly
unknown functions. Circular RNAs require internal ribosome entry sites (IRES) if they are to …

Initiation of translation of most eukaryotic mRNAs commences with 5 end–dependent
recruitment of 40S ribosomal subunits to the mRNA. The 40S subunit carrying the initiator …

Proteins regulating the mammalian target of rapamycin (mTOR), as well as some of the
targets of the mTOR kinase, are overexpressed or mutated in cancer. Rapamycin, the …

Hypoxic stress results in a rapid and sustained inhibition of protein synthesis that is at least
partially mediated by eukaryotic initiation factor 2α (eIF2α) phosphorylation by the …