The variant gambit: COVID-19's next move
More than a year after its emergence, COVID-19, the disease caused by SARS-CoV-2,
continues to plague the world and dominate our daily lives. Even with the development of …
continues to plague the world and dominate our daily lives. Even with the development of …
Projecting the SARS-CoV-2 transition from pandemicity to endemicity: Epidemiological and immunological considerations
In this review, we discuss the epidemiological dynamics of different viral infections to project
how the transition from a pandemic to endemic Severe Acute Respiratory Syndrome …
how the transition from a pandemic to endemic Severe Acute Respiratory Syndrome …
Rapid and parallel adaptive mutations in spike S1 drive clade success in SARS-CoV-2
KE Kistler, J Huddleston, T Bedford - Cell Host & Microbe, 2022 - cell.com
The SARS-CoV-2 pandemic has resulted in numerous virus variants, some of which have
altered receptor-binding or antigenic phenotypes. Here, we quantify the degree to which …
altered receptor-binding or antigenic phenotypes. Here, we quantify the degree to which …
The influenza virus hemagglutinin head evolves faster than the stalk domain
The limited ability of current influenza virus vaccines to protect from antigenically drifted or
shifted viruses creates a public health problem that has led to the need to develop effective …
shifted viruses creates a public health problem that has led to the need to develop effective …
Insights from SARS-CoV-2 sequences
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread across the
globe, so have efforts to sequence its RNA genome. More than 260,000 sequences are now …
globe, so have efforts to sequence its RNA genome. More than 260,000 sequences are now …
The ecology and adaptive evolution of influenza A interspecies transmission
U Joseph, YCF Su, D Vijaykrishna… - Influenza and other …, 2017 - Wiley Online Library
Since 2013, there have been several alarming influenza‐related events; the spread of highly
pathogenic avian influenza H5 viruses into North America, the detection of H10N8 and …
pathogenic avian influenza H5 viruses into North America, the detection of H10N8 and …
Purifying selection determines the short-term time dependency of evolutionary rates in SARS-CoV-2 and pH1N1 influenza
High-throughput sequencing enables rapid genome sequencing during infectious disease
outbreaks and provides an opportunity to quantify the evolutionary dynamics of pathogens in …
outbreaks and provides an opportunity to quantify the evolutionary dynamics of pathogens in …
Divergent evolutionary trajectories of influenza B viruses underlie their contemporaneous epidemic activity
RK Virk, J Jayakumar, IH Mendenhall… - Proceedings of the …, 2020 - National Acad Sciences
Influenza B viruses have circulated in humans for over 80 y, causing a significant disease
burden. Two antigenically distinct lineages (“B/Victoria/2/87-like” and “B/Yamagata/16/88 …
burden. Two antigenically distinct lineages (“B/Victoria/2/87-like” and “B/Yamagata/16/88 …
Discovery of a 382-nt deletion during the early evolution of SARS-CoV-2
To date, the SARS-CoV-2 genome has been considered genetically more stable than SARS-
CoV or MERS-CoV. Here we report a 382-nt deletion covering almost the entire open …
CoV or MERS-CoV. Here we report a 382-nt deletion covering almost the entire open …
An atlas of continuous adaptive evolution in endemic human viruses
KE Kistler, T Bedford - Cell host & microbe, 2023 - cell.com
Through antigenic evolution, viruses such as seasonal influenza evade recognition by
neutralizing antibodies. This means that a person with antibodies well tuned to an initial …
neutralizing antibodies. This means that a person with antibodies well tuned to an initial …