Atrial fibrillation: epidemiology, pathophysiology, and clinical outcomes

L Staerk, JA Sherer, D Ko, EJ Benjamin… - Circulation …, 2017 - Am Heart Assoc
The past 3 decades have been characterized by an exponential growth in knowledge and
advances in the clinical treatment of atrial fibrillation (AF). It is now known that AF genesis …

Atrial fibrillation and stroke

SE Choi, D Sagris, A Hill, GYH Lip… - Expert Review of …, 2023 - Taylor & Francis
Introduction Stroke is one of the leading causes of mortality and morbidity globally. Atrial
fibrillation (AF) is the most common sustained cardiac arrhythmia. It is set to reach epidemic …

EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion–an update

M Glikson, R Wolff, G Hindricks, J Mandrola… - EP …, 2020 - academic.oup.com
This article has been co-published with permission in EP Europace and EuroIntervention. All
rights reserved. VC 2019 the European Heart Rhythm Association and the European …

Mechanisms of thrombogenesis in atrial fibrillation: Virchow's triad revisited

T Watson, E Shantsila, GYH Lip - The Lancet, 2009 - thelancet.com
Atrial fibrillation is the most common sustained cardiac arrhythmia, which is associated with
a high risk of stroke and thromboembolism. Increasing evidence suggests that the …

Atrial fibrillation and the prothrombotic state: revisiting Virchow's triad in 2020

WY Ding, D Gupta, GYH Lip - Heart, 2020 - heart.bmj.com
Atrial fibrillation (AF) is characterised by an increased risk of pathological thrombus
formation due to a disruption of physiological haemostatic mechanisms that are better …

Temporal relationship of atrial tachyarrhythmias, cerebrovascular events, and systemic emboli based on stored device data: a subgroup analysis of TRENDS

EG Daoud, TV Glotzer, DG Wyse, MD Ezekowitz… - Heart rhythm, 2011 - Elsevier
BACKGROUND: The temporal relationship between atrial tachyarrhythmias (atrial
tachycardia [AT] and atrial fibrillation [AF]) and cerebrovascular events/systemic emboli …

The prothrombotic state in atrial fibrillation: pathophysiological and management implications

AA Khan, GYH Lip - Cardiovascular research, 2019 - academic.oup.com
Atrial fibrillation (AF) is the commonest sustained cardiac arrhythmia and is associated with
significant morbidity and mortality. There is plenty of evidence available to support the …

Female sex as an independent risk factor for stroke in atrial fibrillation: possible mechanisms

CL Cove, CM Albert, F Andreotti… - Thrombosis and …, 2014 - thieme-connect.com
Atrial fibrillation (AF) is an independent risk factor for thromboembolism and stroke. Women
with AF are at a higher overall risk for thromboembolic stroke when compared to men with …

Fibrin clot properties in acute ischemic stroke: relation to neurological deficit

A Undas, A Slowik, P Wolkow, A Szczudlik, W Tracz - Thrombosis research, 2010 - Elsevier
INTRODUCTION: Hypercoagulable state occurs in patients with acute vascular events. We
wondered whether clot structure/function is altered in acute ischemic stroke (AIS), like in …

Cerebral thrombi of cardioembolic etiology have an increased content of neutrophil extracellular traps

A Genchi, A Semerano, GS Gullotta, D Strambo… - Journal of the …, 2021 - Elsevier
Background Inflammation is emerging as an essential trigger for thrombosis. In the interplay
between innate immunity and coagulation cascade, neutrophils and neutrophil extracellular …