Introduction Ophthalmic diseases of the retina are a significant cause of vision loss globally.
Despite much progress, there remains an unmet need for durable, long-acting treatment …

Immunogenicity assessment of therapeutic proteins is routinely performed through various
techniques during the drug development process:(i) in silico to design the least …

Native mass spectrometry (MS) is a rapidly advancing field in the analysis of proteins,
protein complexes, and macromolecular species of various types. The majority of native MS …

Therapeutic protein drugs have significantly improved the management of many severe and
chronic diseases. However, their development and optimal clinical application are …

Ion-protein interactions regulate biological processes and are the basis of key strategies of
modulating protein phase diagrams and stability in drug development. Here, we report the …

Introduction: Safety and tolerability is a critical area where improvements are needed to
decrease the attrition rates during development of new drug candidates. Modeling …

The human adaptive immune system is a very complex network of different types of cells,
cytokines, and signaling molecules. This complex network makes it difficult to understand …

The introduction and development of biologics such as therapeutic proteins, gene-, and cell-
based therapy have revolutionized the scope of treatment for many diseases. However, a …

Purpose Protein solubility is an important attribute of pharmaceutical monoclonal antibody
(MAb) formulations, particularly at high MAb concentrations. PEG-induced protein …

The solubility of monoclonal antibodies (mAb) affects their production and their intravenous
administration to patients. In this work, the solubility of a fully glycosylated and a non …