Polymer-mediated protein/peptide therapeutic stabilization: current progress and future directions

RP Sivasankaran, K Snell, G Kunkel, P Georgiou… - Progress in Polymer …, 2024 - Elsevier
Proteins and peptides have played a pivotal role in revolutionizing disease treatment over
the last century. Despite their commercial success, protein therapeutics can be eliminated or …

Ingenious nanoscale medication delivery system: Nanogel

A Garg, K Shah, C singh Chauhan… - Journal of Drug Delivery …, 2024 - Elsevier
Nanogels are a promising drug delivery system as they can hold drugs and macromolecules
and can also respond to external stimuli, which makes them effective tools for various …

Electrostatically mediated in situ polymerization for enzyme immobilization and activation

Y Wan, J Zhou, J Ni, Y Cai, M Cohen Stuart… - …, 2024 - ACS Publications
Enzyme immobilization in nanoparticles is of interest for boosting their catalytic applications,
yet rational approaches to designs achieving both high enzyme loading and activation …

Unlocking Intracellular Protein Delivery by Harnessing Polymersomes Synthesized at Microliter Volumes using Photo‐PISA

C Thanapongpibul, O Rifaie‐Graham… - Advanced …, 2024 - Wiley Online Library
Efficient delivery of therapeutic proteins and vaccine antigens to intracellular targets is
challenging due to generally poor cell membrane permeation and endolysosomal …

Co-assembly-mediated biosupramolecular catalysis: thermodynamic insights into nucleobase specific (oligo) nucleotide attachment and cleavage

S Maiti - Journal of Materials Chemistry B, 2023 - pubs.rsc.org
Gaining control over the stability and cleavage of phosphoester and phosphodiester
remains a matter of interest for their application in biotechnology to oligonucleotide-based …

Furan-rich, biobased transfection agents as potential oligomeric candidates for intracellular plasmid DNA delivery

A Al Hoque, P Kannaboina, Y Abraham, M Mehedi… - RSC …, 2024 - pubs.rsc.org
Biobased, DNA delivery vectors have been synthesized with a core motif composed of 2, 5-
bishydroxymethylfuran (BHMF) readily available from an important biomass feedstock 5 …

Positively Charged Biodegradable Polymersomes with Structure Inherent Fluorescence as Artificial Organelles

RAJF Oerlemans, S Cao, J Wang, Y Li, Y Luo… - …, 2024 - ACS Publications
Polymersomes, nanosized polymeric vesicles, have attracted significant interest in the areas
of artificial cells and nanomedicine. Given their size, their visualization via confocal …

Enzyme-polymer conjugates with photocleavable linkers for control over protein activity

MF Tan, BM Hosier, NL Forsythe, HD Maynard - Polymer Chemistry, 2024 - pubs.rsc.org
Reversible conjugation of polymers to proteins is important for a variety of applications, for
example to control protein activity. Light is often employed as an external trigger to allow for …

Rational Design and Development of Polymeric Nanogels as Protein Carriers

C López‐Iglesias, D Klinger - Macromolecular Bioscience, 2023 - Wiley Online Library
Proteins have gained significant attention as potential therapeutic agents owing to their high
specificity and reduced toxicity. Nevertheless, their clinical utility is hindered by inherent …

[图书][B] Stimulus-Cleavable Linkers for the Controlled Release of Bioactive Molecules: Therapeutic Proteins and Peptides

MF Tan - 2023 - search.proquest.com
Proteins are ubiquitous in numerous pharmaceutical, technological, and industrial
applications. However, these biomolecules are prone to stability issues due to internal …