From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo
D Andergassen, JL Rinn - Nature Reviews Genetics, 2022 - nature.com
Genome-wide sequencing has led to the discovery of thousands of long non-coding RNA
(lncRNA) loci in the human genome, but evidence of functional significance has remained …
(lncRNA) loci in the human genome, but evidence of functional significance has remained …
lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation
Cooperation between DNA, RNA and protein regulates gene expression and controls
differentiation through interactions that connect regions of nucleic acids and protein domains …
differentiation through interactions that connect regions of nucleic acids and protein domains …
Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci
Background The mammalian genome is transcribed into large numbers of long noncoding
RNAs (lncRNAs), but the definition of functional lncRNA groups has proven difficult, partly …
RNAs (lncRNAs), but the definition of functional lncRNA groups has proven difficult, partly …
LncRNAs: the good, the bad, and the unknown
G Arunkumar - Biochemistry and Cell Biology, 2023 - cdnsciencepub.com
Long non-coding RNAs (lncRNAs) are significant contributors in maintaining genomic
integrity through epigenetic regulation. LncRNAs can interact with chromatin-modifying …
integrity through epigenetic regulation. LncRNAs can interact with chromatin-modifying …
Individual long non-coding RNAs have no overt functions in zebrafish embryogenesis, viability and fertility
Hundreds of long non-coding RNAs (lncRNAs) have been identified as potential regulators
of gene expression, but their functions remain largely unknown. To study the role of lncRNAs …
of gene expression, but their functions remain largely unknown. To study the role of lncRNAs …
Mouse knockout models reveal largely dispensable but context-dependent functions of lncRNAs during development
Dear Editor, In mammalian genomes, pervasive transcription produces thousands of long
noncoding RNA (lncRNA) transcripts (Djebali et al., 2012; Hon et al., 2017). Compared to …
noncoding RNA (lncRNA) transcripts (Djebali et al., 2012; Hon et al., 2017). Compared to …
Self-organized formation of developing appendages from murine pluripotent stem cells
S Mori, E Sakakura, Y Tsunekawa, M Hagiwara… - Nature …, 2019 - nature.com
Limb development starts with the formation of limb buds (LBs), which consist of tissues from
two different germ layers; the lateral plate mesoderm-derived mesenchyme and ectoderm …
two different germ layers; the lateral plate mesoderm-derived mesenchyme and ectoderm …
RNA, genome output and input
RNA, the transcriptional output of genomes, not only templates protein synthesis or directly
engages in catalytic functions, but can feed back to the genome and serve as regulatory …
engages in catalytic functions, but can feed back to the genome and serve as regulatory …
Transcriptome dynamics in early zebrafish embryogenesis determined by high-resolution time course analysis of 180 successive, individual zebrafish embryos
H Rauwerda, JFB Pagano, WC de Leeuw, W Ensink… - BMC genomics, 2017 - Springer
Background Recently, much progress has been made in the field of gene-expression in
early embryogenesis. However, the dynamic behaviour of transcriptomes in individual …
early embryogenesis. However, the dynamic behaviour of transcriptomes in individual …
Expression profile of long noncoding RNAs and comprehensive analysis of lncRNA-cisTF-DGE regulation in condyloma acuminatum
B Xie, Y Wu, S Wang, L Ruan, X Liu - BMC Medical Genomics, 2024 - Springer
Objective To identify differentially expressed long noncoding RNAs (lncRNAs) in condyloma
acuminatum (CA) and to explore their probable regulatory mechanisms by establishing …
acuminatum (CA) and to explore their probable regulatory mechanisms by establishing …