Sickle cell anemia (SCA or SS homozygous sickle cell disease) is an inherited blood
disorder caused by single nucleotide substitution in the ß-globin gene that renders their …

Hypoxemia is common in SCD and likely exacerbates SCD vasculopathy. Pulse oximeter
correlation with arterial oxygen tension in patients with SCD may at times be poor and …

Rationale: Sickle cell disease (SCD) results in significant morbidity and mortality attributable
to pulmonary complications. The pattern of lung function change across childhood in SCD is …

Hemoglobinopathies are diseases caused by genetic mutations that result in abnormal,
dysfunctional hemoglobin molecules or lower levels of normal hemoglobin molecules. The …

While a doctor‐diagnosis of asthma is associated with an increased risk of pain and acute
chest syndrome (ACS) in children with sickle cell anemia (SCA), little is known about the …

Introduction Acute chest syndrome (ACS) in sickle cell disease (SCD) is a serious condition
that carries with it a high rate of morbidity and mortality. Objective This review highlights the …

A physician diagnosis of asthma in children and adults with sickle cell disease (SCD) has
been associated with increased rates of pain and acute chest syndrome (ACS) episodes …

Summary Objectives and Working Hypothesis Airways obstruction occurs in young children
with sickle cell disease (SCD). Our aim was to test the hypothesis that increased pulmonary …

Recent studies have emphasized the presence of airway hyperreactivity (AHR) in children
with sickle cell disease (SCD). However, various tests for the detection of AHR have yielded …

To assess the associations between a doctor diagnosis of asthma and wheezing
(independent of a diagnosis of asthma) with sickle cell disease (SCD) morbidity, we …