From naturally-sourced protease inhibitors to new treatments for fungal infections

D Gutierrez-Gongora, J Geddes-McAlister - Journal of Fungi, 2021 - mdpi.com
Proteases are involved in a broad range of physiological processes, including host invasion
by fungal pathogens, and enzymatic inhibition is a key molecular mechanism controlling …

Gliptins in managing diabetes-Reviewing computational strategy

P Sneha, CGP Doss - Life Sciences, 2016 - Elsevier
The pace of anti-diabetic drug discovery is very slow in spite of increasing rate of prevalence
of Type 2 Diabetes which remains a major public health concern. Though extensive …

[HTML][HTML] Taurine drives body protein renewal and accretion in beef steers

S Zhang, J Hu, Y Liu, X Shen, C Liu, L Cheng, M Li… - Animal Nutrition, 2024 - Elsevier
The aims of the present study were to investigate the effects of dietary supplementation with
rumen-protected taurine (RPT) on whole-body protein turnover, plasma metabolomics, and …

[图书][B] Sustainable Chemistry Research: Chemical and Biochemical Aspects

P Ramasami - 2023 - books.google.com
This edited book of proceedings is a collection of nineteen selected and peer-reviewed
contributions from the Virtual Conference on Chemistry and its Applications (VCCA-2022) …

The protease-based compensatory mechanism to minimize the effect of dietary Soybean Trypsin Inhibitor in Litopenaeus vannamei

L Rojo-Arreola, C Choquet, J Cordova-Murueta… - Aquaculture, 2019 - Elsevier
Soybean meal is a recurrent ingredient in shrimp feed formulations; although economically
convenient, the downside is the antinutritional molecules often present in its active forms …

Assessing the putative anticryptococcal properties of crude and clarified extracts from mollusks

D Gutierrez-Gongora, F Raouf-Alkadhimi… - JoVE (Journal of …, 2022 - jove.com
Cryptococcus neoformans is an encapsulated human fungal pathogen with a global
distribution that primarily infects immunocompromised individuals. The widespread use of …

Aqueous extracts of marine invertebrates from Cuba coastline display neutral aminopeptidase inhibitory activities and effects on cancer cells and Plasmodium …

I Pascual Alonso, L Bounaadja, L Sánchez… - Indian Journal of …, 2017 - op.niscpr.res.in
Neutral aminopeptidases are enzymes distributed in all living organisms. By hydrolyzing
biologically active peptides in tissues and biological fluids, they are involved in the control of …

Dipeptidyl peptidase IV: a multifunctional enzyme with implications in several pathologies including cancer

Y Arrebola Sánchez, F Almeida García… - Physical Sciences …, 2024 - degruyter.com
Ectopeptidases are particularly interesting due to their potential to regulate/dysregulate the
peptide mediated signaling cellular pathways because the active site located to the …

Marine Invertebrates: A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families

I Pascual Alonso, F Almeida García… - Marine drugs, 2023 - mdpi.com
Proteolytic enzymes, also known as peptidases, are critical in all living organisms.
Peptidases control the cleavage, activation, turnover, and synthesis of proteins and regulate …

CogiTx1: A novel subtilisin A inhibitor isolated from the sea anemone Condylactis gigantea belonging to the defensin 4 protein family

L Rojas, A Cabrera-Muñoz, LA Espinosa, S Montané… - Biochimie, 2023 - Elsevier
Subtilisin-like enzymes are recognized as key players in many infectious agents. In this
context, its inhibitors are very valuable molecular lead compounds for structure based drug …