Sarcoidosis is characterized by noncaseating granulomas which form in almost any part of
the body, primarily in the lungs and/or thoracic lymph nodes. Environmental exposures in …

Sarcoidosis is a granulomatous multiorgan disease, thought to result from exposure to yet
unidentified antigens in genetically susceptible individuals. The exaggerated inflammatory …

Pseudo-progression and flare-up phenomena constitute a novel diagnostic challenge in the
follow-up of patients treated with immune-oncology drugs. We present a case study on …

Sarcoidosis is an immune-mediated disorder. Its immunopathology has been steadily
mapped out over the past few decades. Despite this, the underpinning mechanisms for …

Rationale Disease course in sarcoidosis is highly variable. Bronchoalveolar lavage fluid and
mediastinal lymph nodes show accumulation of activated T cells with a T-helper (Th) 17.1 …

Motivation Single-cell RNA sequencing (scRNA-seq) data are important for studying the
laws of life at single-cell level. However, it is still challenging to obtain enough high-quality …

CD4+ T cells are key mediators of various autoimmune diseases; however, their role in
disease progression remains unclear due to cellular heterogeneity. Here, we evaluated …

Rationale: Chronic sarcoidosis is a complex granulomatous disease with limited treatment
options that can progress over time. Understanding the molecular pathways contributing to …

Understanding the factors that influence the biological response to inflammation is crucial,
due to its involvement in physiological and pathological processes, including tissue …

Introduction In sarcoidosis, peripheral lymphopenia and anergy have been associated with
increased inflammation and maladaptive immune activity, likely promoting development of …