Drosophila tools and assays for the study of human diseases

B Ugur, K Chen, HJ Bellen - Disease models & mechanisms, 2016 - journals.biologists.com
Many of the internal organ systems of Drosophila melanogaster are functionally analogous
to those in vertebrates, including humans. Although humans and flies differ greatly in terms …

Methods for studying metabolism in Drosophila

JM Tennessen, WE Barry, J Cox, CS Thummel - Methods, 2014 - Elsevier
Recent research using Drosophila melanogaster has seen a resurgence in studies of
metabolism and physiology. This review focuses on major methods used to conduct this …

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

WB Dunn, D Broadhurst, P Begley, E Zelena… - Nature protocols, 2011 - nature.com
Metabolism has an essential role in biological systems. Identification and quantitation of the
compounds in the metabolome is defined as metabolic profiling, and it is applied to define …

Metabolite identification and quantitation in LC-MS/MS-based metabolomics

JF Xiao, B Zhou, HW Ressom - TrAC Trends in Analytical Chemistry, 2012 - Elsevier
Metabolomics aims at detection and quantitation of all metabolites in biological samples.
The presence of metabolites with a wide variety of physicochemical properties and different …

HILIC‐MS for metabolomics: An attractive and complementary approach to RPLC‐MS

DQ Tang, L Zou, XX Yin, CN Ong - Mass spectrometry reviews, 2016 - Wiley Online Library
Hydrophilic interaction chromatography (HILIC) is an emerging separation mode of liquid
chromatography (LC). Using highly hydrophilic stationary phases capable of retaining …

[图书][B] Mechanisms of life history evolution: the genetics and physiology of life history traits and trade-offs

T Flatt, A Heyland - 2011 - books.google.com
Life history theory seeks to explain the evolution of the major features of life cycles by
analyzing the ecological factors that shape age-specific schedules of growth, reproduction …

High resolution mass spectrometry

F Xian, CL Hendrickson, AG Marshall - Analytical chemistry, 2012 - ACS Publications
This review focuses on recent advances in instrumentation, techniques, and applications of
the highest resolution mass analyzers (multipass time of flight (TOF), orbitrap, and Fourier …

Model population analysis for variable selection

HD Li, YZ Liang, QS Xu, DS Cao - Journal of Chemometrics, 2010 - Wiley Online Library
To build a credible model for given chemical or biological or clinical data, it may be helpful to
first get somewhat better insight into the data itself before modeling and then to present the …

Coupling liquid chromatography to Orbitrap mass spectrometry

A Makarov, M Scigelova - Journal of Chromatography A, 2010 - Elsevier
The Orbitrap mass analyzer has become a mainstream mass spectrometry technique. In
addition to providing a brief introduction to the Orbitrap technology and its continuing …

Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics

M Brown, WB Dunn, P Dobson, Y Patel, CL Winder… - Analyst, 2009 - pubs.rsc.org
The chemical identification of mass spectrometric signals in metabolomic applications is
important to provide conversion of analytical data to biological knowledge about metabolic …