Peroxisomes are key regulators of cellular and metabolic homeostasis. These organelles
play important roles in redox metabolism, the oxidation of very-long-chain fatty acids …

Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and rapidly transported
into the organelle by a complex machinery. The data gathered in recent years suggest that …

Abstract p97 processes ubiquitinated substrates and plays a central role in cellular protein
homeostasis. Here, we report a series of cryo-EM structures of the substrate-engaged …

Peroxisome biogenesis disorders (PBD) are a group of conditions caused by a partial or
generalized defect in peroxisome biogenesis. They encompass two phenotypic groups: 1 …

The AAA-ATPases Pex1 and Pex6 are required for the formation and maintenance of
peroxisomes, membrane-bound organelles that harbor enzymes for specialized metabolism …

PEX1 and PEX6 are two members of the ATPases associated with diverse cellular activities
(AAA) family and the core components of the receptor export module of the peroxisomal …

Peroxisomes are highly dynamic, oxidative organelles with key metabolic functions in
cellular lipid metabolism, such as the β-oxidation of fatty acids and the synthesis of myelin …

The double-ring AAA+ ATPase Pex1/Pex6 is required for peroxisomal receptor recycling
and is essential for peroxisome formation. Pex1/Pex6 mutations cause severe peroxisome …

Peroxisome biogenesis disorders (PBDs) is a group of diseases caused by mutations in one
of the peroxins, proteins responsible for biogenesis of the peroxisomes. In recent years, it …

Peroxisomal integrity and function are highly dependent on its membrane and soluble
(matrix) components. Matrix enzymes are imported post-translationally in a folded or even …