Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit
signals from their receptors to regulate gene expression and prevent apoptosis. Some …

Background Prostate cancer continues to be the most common lethal malignancy diagnosed
in American men and the second leading cause of male cancer mortality. The American …

Pathway analysis is often the first choice for studying the mechanisms underlying a
phenotype. However, conventional methods for pathway analysis do not take into account …

Androgen receptor (AR) plays a central role in prostate cancer, and most patients respond to
androgen deprivation therapies, but they invariably relapse with a more aggressive prostate …

Targeting androgen receptor (AR) axis signaling by disrupting androgen-AR interactions
remains the primary treatment for metastatic prostate cancer. Unfortunately, all men develop …

With∼ 30 000 deaths annually in the United States, prostate cancer (PCa) is a major
oncologic disease. Here we show that the microRNAs miR-130a, miR-203 and miR-205 …

The transcriptional programs regulated through the activity of the androgen receptor (AR)
modulate normal prostate development and the maintenance of prostatic functions at …

An increasing amount of data supports an inverse association between statin use and
cancer risk. The findings for prostate cancer, particularly advanced disease, are the most …

Androgen deprivation therapy (ADT) is considered as the standard therapy for men with de
novo or recurrent metastatic prostate cancer. ADT commonly leads to initial biochemical and …

Prostate specific antigen (PSA) is a serine protease that is synthesized by both normal and
malignant epithelial cells of the human prostate. PSA expressed by malignant cells …