Much is known about skeletal adaptation in relation to the mechanical functions that bones
serve. This includes how bone adapts to mechanical loading during an individual's lifetime …

In vivo, tibial loading in mice is increasingly used to study bone adaptation and
mechanotransduction. To achieve standardized and defined experimental conditions …

Organisms rely on mechanosensing mechanisms to adapt to changes in their mechanical
environment. Fluid-filled network structures not only ensure efficient transport but can also …

Physical activity is essential to maintain skeletal mass and structure, but its effect seems to
diminish with age. To test the hypothesis that bone becomes less sensitive to mechanical …

Mechanical stimuli including loading after birth promote bone growth. However, little is
known about how mechanical force triggers biochemical signals to regulate bone growth …

Dynamic processes modify bone micro-structure to adapt to external loading and avoid
mechanical failure. Age-related cortical bone loss is thought to occur because of increased …

Abstract Purpose of the Review Bone adapts structure and material properties in response
to its mechanical environment, a process called mechanoadpatation. For the past 50 years …

Bone is a dynamic tissue and adapts its architecture in response to biological and
mechanical factors. Here we investigate how cortical bone formation is spatially controlled …

Strain-induced adaption of bone has been well-studied in an axial loading model of the
mouse tibia. However, most outcomes of these studies are restricted to changes in bone …

Abstract Purpose of Review Osteoporosis is an age-related disorder characterized by bone
loss and increased fracture susceptibility. Whether this is due to reduced loading in less …