Conus venom peptide pharmacology

RJ Lewis, S Dutertre, I Vetter, MDJ Christie… - Pharmacological …, 2012 - Elsevier
Conopeptides are a diverse group of recently evolved venom peptides used for prey capture
and/or defense. Each species of cone snails produces in excess of 1000 conopeptides, with …

The hitchhiker's guide to the voltage-gated sodium channel galaxy

CA Ahern, J Payandeh, F Bosmans… - Journal of General …, 2016 - rupress.org
Eukaryotic voltage-gated sodium (Nav) channels contribute to the rising phase of action
potentials and served as an early muse for biophysicists laying the foundation for our current …

Conus venoms-a rich source of peptide-based therapeutics

TS Han, RW Teichert, BM Olivera… - Current pharmaceutical …, 2008 - ingentaconnect.com
Over two decades of research on venom peptides derived from cone snails (“conopeptides
or conotoxins”) has led to several compounds that have reached human clinical trials, most …

μO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits

J Ekberg, A Jayamanne, CW Vaughan… - Proceedings of the …, 2006 - National Acad Sciences
The tetrodotoxin-resistant voltage-gated sodium channel (VGSC) Nav1. 8 is expressed
predominantly by damage-sensing primary afferent nerves and is important for the …

Sodium channels and pain: From toxins to therapies

FC Cardoso, RJ Lewis - British journal of pharmacology, 2018 - Wiley Online Library
Voltage‐gated sodium channels (NaV channels) are essential for the initiation and
propagation of action potentials that critically influence our ability to respond to a diverse …

Conotoxins down under

RS Norton, BM Olivera - Toxicon, 2006 - Elsevier
In the four decades since toxinologists in Australia and elsewhere started to investigate the
active constituents of venomous cone snails, a wealth of information has emerged on the …

Recent developments regarding voltage-gated sodium channel blockers for the treatment of inherited and acquired neuropathic pain syndromes

JW Theile, TR Cummins - Frontiers in pharmacology, 2011 - frontiersin.org
Chronic and neuropathic pain constitute significant health problems affecting millions of
individuals each year. Pain sensations typically originate in sensory neurons of the …

Chemical modification of conotoxins to improve stability and activity

DJ Craik, DJ Adams - ACS chemical biology, 2007 - ACS Publications
Conotoxins are small disulfide-rich peptides from the venom of cone snails. Along with other
conopeptides, they target a wide range of membrane receptors, ion channels, and …

Voltage-gated sodium channels

K Kwong, MJ Carr - Current opinion in pharmacology, 2015 - Elsevier
Highlights•Voltage-gated sodium channels (Na V) play a key role in neuronal
excitability.•Individual nerves express multiple Na V subtypes.•Many Na V mutations are …

Conotoxins targeting voltage-gated sodium ion channels

S Pei, N Wang, Z Mei, D Zhangsun, DJ Craik… - Pharmacological …, 2024 - Elsevier
Voltage-gated sodium (Na V) channels are intimately involved in the generation and
transmission of action potentials, and dysfunction of these channels may contribute to …