Abstract tRNAs are key partners in ribosome-dependent protein synthesis. This process is
highly dependent on the fidelity of tRNA aminoacylation by aminoacyl-tRNA synthetases …

▪ Abstract Aminoacyl-tRNAs are substrates for translation and are pivotal in determining how
the genetic code is interpreted as amino acids. The function of aminoacyl-tRNA synthesis is …

Nonsense suppression therapy encompasses approaches aimed at suppressing translation
termination at in-frame premature termination codons (PTCs, also known as nonsense …

Correct expression of the genetic code at translation is directly correlated with tRNA identity.
This survey describes the molecular signals in tRNAs that trigger specific aminoacylations …

Several significant steps have been completed toward a general method for the site-specific
incorporation of unnatural amino acids into proteins in vivo. An “orthogonal” suppressor …

Aminoacyl-tRNA synthetases (aaRS) ensure the faithful transmission of genetic information
in all living cells. The 24 known aaRS families are divided into 2 structurally distinct classes …

In an effort to expand the scope of protein mutagenesis, we have completed the first steps
toward a general method to allow the site-specific incorporation of unnatural amino acids …

Aminoacyl-tRNA synthetases (aaRS) are the enzymes that ensure faithful transmission of
genetic information in all living cells, and are central to the developing technologies for …

During fermentative growth in natural and industrial environments, Saccharomyces
cerevisiae must redistribute the available nitrogen from multiple exogenous sources to …

The pyrrolysyl-tRNA synthetase (PylRS) facilitates the cotranslational installation of the 22nd
amino acid pyrrolysine. Owing to its tolerance for diverse amino acid substrates, and its …