A review of cytokine-based pathophysiology of Long COVID symptoms

RN Low, RJ Low, A Akrami - Frontiers in Medicine, 2023 - frontiersin.org
The Long COVID/Post Acute Sequelae of COVID-19 (PASC) group includes patients with
initial mild-to-moderate symptoms during the acute phase of the illness, in whom recovery is …

Microglial subtypes: diversity within the microglial community

V Stratoulias, JL Venero, MÈ Tremblay… - The EMBO journal, 2019 - embopress.org
Microglia are brain‐resident macrophages forming the first active immune barrier in the
central nervous system. They fulfill multiple functions across development and adulthood …

Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines

P Cao, C Chen, A Liu, Q Shan, X Zhu, C Jia, X Peng… - Neuron, 2021 - cell.com
Early-life inflammation increases the risk for depression in later life. Here, we demonstrate
how early-life inflammation causes adolescent depressive-like symptoms: by altering the …

Neuropathobiology of COVID-19: the role for glia

ME Tremblay, C Madore, M Bordeleau… - Frontiers in cellular …, 2020 - frontiersin.org
SARS-CoV-2, which causes the Coronavirus Disease 2019 (COVID-19) pandemic, has a
brain neurotropism through binding to the receptor angiotensin-converting enzyme 2 …

SARS-CoV-2 infection of microglia elicits proinflammatory activation and apoptotic cell death

GU Jeong, J Lyu, KD Kim, YC Chung… - Microbiology …, 2022 - Am Soc Microbiol
Accumulating evidence suggests that severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection causes various neurological symptoms in patients with coronavirus …

Neuroinflammation in frontotemporal dementia

F Bright, EL Werry, C Dobson-Stone, O Piguet… - Nature Reviews …, 2019 - nature.com
Frontotemporal dementia (FTD) refers to a group of progressive neurodegenerative
disorders with different pathological signatures, genetic variability and complex disease …

Microglia, lifestyle stress, and neurodegeneration

C Madore, Z Yin, J Leibowitz, O Butovsky - Immunity, 2020 - cell.com
Recent years have witnessed a revolution in our understanding of microglia biology,
including their major role in the etiology and pathogenesis of neurodegenerative diseases …

Human fetal microglia acquire homeostatic immune-sensing properties early in development

L Kracht, M Borggrewe, S Eskandar, N Brouwer… - Science, 2020 - science.org
Microglia, immune cells of the central nervous system (CNS), are important for tissue
development and maintenance and are implicated in CNS disease, but we lack …

The emerging tale of microglia in psychiatric disorders

R Rahimian, M Wakid, LA O'Leary… - … & Biobehavioral Reviews, 2021 - Elsevier
As the professional phagocytes of the brain, microglia orchestrate the immunological
response and play an increasingly important role in maintaining homeostatic brain functions …

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain

C Madore, Q Leyrolle, L Morel, M Rossitto… - Nature …, 2020 - nature.com
Abstract Omega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of the
brain. Westernization of dietary habits in both developed and developing countries is …