The pyruvate dehydrogenase complex: Life's essential, vulnerable and druggable energy homeostat

PW Stacpoole, CE McCall - Mitochondrion, 2023 - Elsevier
Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …

Suspended in time: molecular responses to hibernation also promote longevity

R Al-Attar, KB Storey - Experimental Gerontology, 2020 - Elsevier
Aging in most animals is an inevitable process that causes or is a result of physiological,
biochemical, and molecular changes in the body, and has a strong influence on an …

Waking the sleeping dragon: gene expression profiling reveals adaptive strategies of the hibernating reptile Pogona vitticeps

A Capraro, D O'Meally, SA Waters, HR Patel… - BMC genomics, 2019 - Springer
Background Hibernation is a physiological state exploited by many animals exposed to
prolonged adverse environmental conditions associated with winter. Large changes in …

Advances and applications of environmental stress adaptation research

LJ Hawkins, KB Storey - Comparative Biochemistry and Physiology Part A …, 2020 - Elsevier
Evolution has produced animals that survive extreme fluctuations in environmental
conditions including freezing temperatures, anoxia, desiccating conditions, and prolonged …

A functional transcriptomic analysis in the relict marsupial Dromiciops gliroides reveals adaptive regulation of protective functions during hibernation

RF Nespolo, JD Gaitan‐Espitia… - Molecular …, 2018 - Wiley Online Library
Abstract The small South American marsupial, Dromiciops gliroides, known as the missing
link between the American and the Australian marsupials, is one of the few South American …

Metabolic reorganization in winter: Regulation of pyruvate dehydrogenase (PDH) during long-term freezing and anoxia

R Al-Attar, S Wijenayake, KB Storey - Cryobiology, 2019 - Elsevier
Wood frogs, Rana sylvatica, can undergo prolonged periods of whole body freezing during
winter, locking as much as 65–70% of total body water into extracellular ice and imposing …

Integrated Redox-Metabolic Orchestration Sustains Life in Hibernating Ground Squirrels

A Jankovic, A Kalezic, A Korac, B Buzadzic… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: The ultimate manifestations of life, birth, survival under various environmental
pressures and death are based on bioenergetics. Hibernation is a unique survival strategy …

The living dead: mitochondria and metabolic arrest

H Hadj‐Moussa, SR Green, KB Storey - IUBMB life, 2018 - Wiley Online Library
Mitochondria are not just the powerhouses of the cell; these 'end of function'organelles are
crucial components of cellular physiology and influence many central metabolic and …

Local adaptation of Dromiciops marsupials (Microbiotheriidae) from southern South America: Implications for species management facing climate change

JF Quintero‐Galvis, P Saenz‐Agudelo… - Ecology and …, 2024 - Wiley Online Library
The two species of the microbiotheriid marsupial genus Dromiciops (Dromiciops
bozinovici:“Panchos's monito del monte” and Dromiciops gliroides:“monito del monte”) …

Molecular control of protein synthesis, glucose metabolism, and apoptosis in the brain of hibernating thirteen-lined ground squirrels

SN Tessier, CW Wu, KB Storey - Biochemistry and Cell Biology, 2019 - cdnsciencepub.com
Thirteen-lined ground squirrels (Ictidomys tridecemlineatus) are excellent models for
studying acute brain ischemia because they show high resistance to reductions in blood …