Protein phosphorylation is a crucial regulator of protein and cellular function, yet, despite
identifying an enormous number of phosphorylation sites, the role of most is still unclear …

Posttranslational modifications, typically small chemical tags attached on amino acids
following protein biosynthesis, have a profound effect on protein structure and function …

Phosphorylation is a major constituent of the CTD code, which describes the set of post-
translational modifications on 52 repeats of a YSPTSPS consensus heptad that orchestrates …

The control of malaria, a disease caused by Plasmodium parasites that kills over half a
million people every year, is threatened by the continual emergence and spread of drug …

Trimethyllysine is an important post-translationally modified amino acid with functions in the
carnitine biosynthesis and regulation of key epigenetic processes. Protein lysine …

Peptide–drug conjugates (PDCs) have recently emerged as interesting hybrid constructs not
only for targeted therapy, but also for the early diagnosis of different pathologies. In most …

Thioesters are considered to be “energy-rich” functional groups that are susceptible to attack
by thiolate and amine nucleophiles while remaining hydrolytically stable at neutral pH …

Proteins labelled site-specifically with small molecules are valuable assets for chemical
biology and drug development. The unique reactivity profile of the 1, 2-aminothiol moiety of …

We present the first demonstration of ligand-induced conformational changes in a biological
molecule, a protein, by sum-frequency generation (SFG). Constructs of KRas G12D protein …

In this work, we developed a novel strategy, prior disulfide bond-mediated Ser/Thr ligation
(PD-STL), for the chemical synthesis of peptides and proteins. This approach combines …