Low back pain is a highly prevalent, chronic, and costly medical condition predominantly
triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and …

The cartilaginous endplates (CEP) are key components of the intervertebral disc (IVD)
necessary for sustaining the nutrition of the disc while distributing mechanical loads and …

Objectives Modic type 1 changes (MC1) are vertebral endplate bone marrow (BM) lesions
observed on magnetic resonance images in sub-populations of chronic low back pain …

Introduction Alzheimer's (AD) and Parkinson's disease (PD) are neurodegenerative
conditions characterized by incremental deposition of β-amyloid (Aβ) and α-synuclein in AD …

Disc degeneration and vertebral endplate bone marrow lesions called Modic changes are
prevalent spinal pathologies found in chronic low back pain patients. Their …

In the last decade, several studies have demonstrated Cutibacterium acnes colonization in
intervertebral discs (IVDs) in patients with lumbar disc degeneration (LDD) and low back …

Simple Summary Cutibacterium acnes, a common bacterium on human skin, is a causative
agent of inflammatory skin diseases and systemic infections. Systemic infections caused by …

Propionibacterium acnes infection in intervertebral discs (IVDs) is a newly identified cause of
low back pain (LBP). In the present study, we aimed to determine whether the nerve growth …

To understand the pathophysiology of spondylodiscitis due to Staphylococcus aureus, an
emerging infectious disease of the intervertebral disc (IVD) and vertebral body with a high …

Extracellular matrix (ECM) metabolism disorders in the inflammatory microenvironment play
a key role in the pathogenesis of intervertebral disc degeneration (IDD). Interleukin-32 (IL …